Effects of Exercise Training on Health-related Quality of Life in Patients With Unresectable Metastatic Colorectal Cancer: A Multi-center Randomized Controlled Trial

What this Trial Is About

Researchers are evaluating the effects of 18 weeks of structured exercise training compared to standard care on the health-related quality of life in adults with metastatic colorectal cancer receiving first-line chemotherapy. The study aims to understand how exercise may influence quality of life during cancer treatment and is sponsored by Rigshospitalet, Denmark. Participants are randomly assigned to one of two groups. One group receives standard care without exercise restrictions. The other group receives standard care plus a combined resistance and aerobic exercise program involving moderate-to-high intensity supervised and unsupervised home-based activities such as bicycling, walking, or running, performed five times per week for 18 weeks. After this initial period, participants can choose to continue the exercise program until week 162. During the study, participants' health-related quality of life is assessed every three weeks up to 18 weeks and at longer follow-up intervals up to 156 weeks. Other measurements include cancer symptoms, fatigue, adverse events, physical performance tests, body composition, vital signs, and survival outcomes. Safety monitoring includes reporting hospitalizations, chemotherapy dose changes, and serious adverse events. The total participation may last up to five years, including extended follow-up for long-term outcomes.

Randomized Controlled Trial of the Effects of Combined Resistance and AerobiC Exercise on Health-related Quality of Life in Patients Undergoing First-line Chemotherapy for Metastatic Colorectal Cancer (REACH)