Study of Recovery Over Time After Coma Caused by Serious Brain Injury or Illness

What this Trial Is About

Researchers are studying recovery patterns in adults who have been in a coma or have disorders of consciousness caused by serious neurological illnesses or injuries, such as stroke, cardiac arrest, traumatic brain injury, seizures, brain infections, and other emergencies. This observational study aims to identify medical, neurological, psychological, and social factors that influence recovery over time. The study does not involve any experimental treatments and will not affect the medical care participants receive. Participants are adults hospitalized with coma or disorders of consciousness due to acute neurological injury or illness. They are enrolled during their hospital stay and followed after discharge. Researchers collect information from medical records about the illness, treatments, brain imaging, and neurological exams during hospitalization. After hospital discharge, participants or their caregivers are contacted at scheduled times to assess recovery using questionnaires and interviews focused on physical function, quality of life, emotional well-being, and daily activities. Throughout the study, recovery is measured using several tools including the Modified Rankin Scale and Glasgow Outcome Scale Extended at multiple time points up to 48 months and beyond. Additional assessments include quality of life, social determinants of health, depression, and anxiety questionnaires. This long-term follow-up helps researchers better understand recovery trajectories after coma and disorders of consciousness. Participation involves no interventions, and data collection occurs through medical records and structured assessments over several years.

Recovery Trajectory for Coma and Disorders of Consciousness