Actively Recruiting
Recovery Trajectory for Coma and Disorders of Consciousness
Led by University of California, San Francisco · Updated on 2026-06-02
2000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
Z
Zuckerberg San Francisco General Hospital and Trauma Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying recovery patterns in adults who have been in a coma or have disorders of consciousness caused by serious neurological illnesses or injuries, such as stroke, cardiac arrest, traumatic brain injury, seizures, brain infections, and other emergencies. This observational study aims to identify medical, neurological, psychological, and social factors that influence recovery over time. The study does not involve any experimental treatments and will not affect the medical care participants receive. Participants are adults hospitalized with coma or disorders of consciousness due to acute neurological injury or illness. They are enrolled during their hospital stay and followed after discharge. Researchers collect information from medical records about the illness, treatments, brain imaging, and neurological exams during hospitalization. After hospital discharge, participants or their caregivers are contacted at scheduled times to assess recovery using questionnaires and interviews focused on physical function, quality of life, emotional well-being, and daily activities. Throughout the study, recovery is measured using several tools including the Modified Rankin Scale and Glasgow Outcome Scale Extended at multiple time points up to 48 months and beyond. Additional assessments include quality of life, social determinants of health, depression, and anxiety questionnaires. This long-term follow-up helps researchers better understand recovery trajectories after coma and disorders of consciousness. Participation involves no interventions, and data collection occurs through medical records and structured assessments over several years.
CONDITIONS
Brief Title
Recovery Trajectory for Coma and Disorders of Consciousness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older on the day of hospital admission
- Coma lasting at least 24 hours from hospital presentation or death before 24 hours without regaining consciousness
- Coma defined by Glasgow Coma Scale (GCS) scores: total ≤10, motor component <6 (not following commands), verbal component <3, and altered consciousness not explained by sedation alone
- Coma caused by neurological processes such as trauma, stroke, hypoxic-ischemic brain injury, CNS infection, seizure, or other related causes
- Admission to intensive care unit or deceased before ICU admission
You will not qualify if you...
- Pre-existing motor GCS score ≤5 before hospital admission
- Transfer from another acute care hospital without known or reconstructible motor GCS on day after arrival
- Coma caused by sepsis or systemic metabolic conditions like organ failure or sedation
- GCS eye opening >2 with lack of command following due to focal brain lesion causing receptive aphasia
- Prisoner
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) during hospitalization
Duration - Up to 48 months after coma onset, with continued assessments every 6 months thereafter until study completion
Participants are followed longitudinally after hospital discharge to assess functional recovery, quality of life, emotional well-being, and other patient-centered outcomes.
Regular assessments at 1, 3, 6, 9, 12, 15, 18, 21, 24, 30, 36, 42, and 48 months after coma onset, then every 6 months
Trial Site Locations
Total: 1 location
1
Zuckerberg San Francisco General Hospital and Trauma Center
San Francisco, California, United States, 94110
Actively Recruiting
Research Team
C
Claude Hemphill, MD, MAS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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