Relaxin Measurement in Different Endometrial Preparation Approaches for Frozen Embryo Transfer

What this Trial Is About

Researchers are investigating the levels of Relaxin hormone in different methods of preparing the endometrium for frozen embryo transfer (FET) cycles. The study explores whether ovulation with a functional corpus luteum (CL) occurs during a natural proliferative phase (NPP) endometrial preparation, as this remains unclear. The trial also addresses concerns about how preparation methods impact pregnancy outcomes, such as risks for bleeding, miscarriage, and pregnancy-related hypertension. The study observes three types of endometrial preparation: a natural cycle, a natural proliferative phase cycle where follicle growth is monitored and progesterone is given before spontaneous ovulation, and a hormonal replacement therapy (HRT) cycle involving estrogen and progesterone. The NPP protocol includes progesterone alone to induce secretory changes, while the HRT protocol combines estrogen and progesterone. Researchers aim to measure Relaxin levels in these different approaches. Participants will be monitored over 4 to 6 months to measure Relaxin hormone levels. This observational study involves tracking menstrual cycles, hormone exposure, and endometrial changes without altering participants' usual care. The main outcome is Relaxin measurement, which may help understand the presence and role of a functional CL in the different preparation methods. Participant involvement includes hormone exposure monitoring and cycle tracking during the study period.

Relaxin Measurement in Different Endometrial Preparation Approaches for Frozen Embryo Transfer