Study of Kidney Problems in Adults With Inflammatory Bowel Disease Compared to the General Population The NEPHRO-IBD Study

What this Trial Is About

Researchers are investigating how often kidney problems occur in adults with inflammatory bowel disease IBD, such as Crohns disease and ulcerative colitis, compared to adults without IBD. This observational study aims to better understand kidney complications in IBD patients, which are often overlooked despite being potentially serious. The study will include about 6,000 participants, half with confirmed IBD and half without, to serve as a control group. Participants will undergo regular clinical assessments including routine blood and urine tests, urinalysis with albumin-to-creatinine ratio measurement, and abdominal ultrasound to examine the kidneys and urinary tract. These tests will be repeated every three to six months. IBD patients will also have their disease activity measured using clinical indices like the Total Mayo Score and Crohns Disease Activity Index, along with fecal calprotectin levels to assess inflammation. During the study, participants will complete questionnaires and undergo laboratory tests and imaging at baseline and follow-up visits approximately every three months, for up to six months. Researchers will track kidney function and assess links between kidney problems, IBD activity, treatments, and other health conditions. The main outcome is the prevalence of kidney dysfunction in IBD patients compared to the general population. The study will help improve early detection and management of kidney disease in people with IBD.

Renal Dysfunction in Patients With Inflammatory Bowel Disease and the General Population (NEPHRO-IBD)