Actively Recruiting
Led by Zhang longjiang,MD · Updated on 2024-11-26
3400
Participants Needed
1
Research Sites
117 weeks
Total Duration
Researchers are investigating whether a heart disease prevention approach using coronary computed tomography angiography (CCTA) can improve the management of cholesterol-lowering treatments and control of cardiovascular risk factors compared to the traditional method based on cardiovascular risk scores. This study focuses on an asymptomatic Chinese population aged 40 to 69 years without known cardiovascular events. It aims to better understand the impact of CCTA screening on personalized prevention strategies and the prevalence of hidden coronary artery disease. Participants will be randomly assigned to one of two groups: one receiving prevention programs guided by CCTA results, and the other managed using traditional cardiovascular risk scores based on Chinese guidelines for lipid management. The study will include baseline assessments with questionnaires and objective evaluations on the same day as consent. Both groups will follow their respective prevention strategies, with lipid-lowering treatment and risk factor control monitored over time. During the 12 months of follow-up, researchers will assess how many participants regularly take lipid-lowering medications and achieve LDL cholesterol targets, as well as monitor cardiovascular events, blood pressure, diabetes control, smoking cessation, exercise habits, and quality of life measures including anxiety and depression. The study will also report on the prevalence of subclinical coronary atherosclerosis detected by CCTA at baseline. The overall participation involves regular assessments to evaluate the effectiveness of the prevention strategies over one year.
CONDITIONS
Role of Coronary CTA on Lipid Management and Risk Factors Control in an Asymptomatic Chinese Population
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline
Participants undergo coronary computed tomography angiography (CCTA) or traditional cardiovascular risk stratification to guide individualized primary prevention programs for coronary heart disease.
1 baseline visit (in-person)
Duration - 12 months
Participants are monitored for lipid-lowering treatment adherence and cardiovascular risk factor control over 12 months.
Follow-up visits to assess treatment adherence and risk factor control
Total: 1 location
1
Research Institute Of Medical Imaging Jinling Hospital
Nanjing, Jiangsu, China, 210018
Actively Recruiting
L
Longjiang Zhang, MD
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Have more questions? Get in touch with our team for quick support
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Xiang Guo, Jianhua Li, Ying Zhu...
https://pubmed.ncbi.nlm.nih.gov/39350195