Comparison potassium sodium hydrogen citrate with sodium bicarbonate in urine alkalization: a prospective crossover-controlled trial.
Wen Xue, Jiafen Cheng, Jing Zhao...
https://pubmed.ncbi.nlm.nih.gov/36261757Status Unknown
Phase Not Applicable
Age: 18Years - 70Years
All Genders
ID04352153
A Randomized, Prospective, Controlled Study of the Efficacy and Safety of Uralyt-U Combined With Febuxostat in the Treatment of Hyperuricemia With Uric Acid Stones
Led by Ai Peng · Updated on 2020-04-20
102
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to provide a more direct and objective basis for the widespread use of potassium sodium hydrogen citrate granules in the treatment of uric acid stones.
CONDITIONS
Brief Title
Role of Uralyt-U in Patients With Hyperuricemia
Who Can Participate
Age: 18Years - 70Years
All Genders
Eligibility Criteria
You may qualify if you...
- 18-70 years old, male, outpatient or inpatient;
- Acidic urinary stones
- Serum uric acid value ≥480 µmol / L;
- Other concomitant diseases (such as hypertension, hyperlipidemia, diabetes, etc.) are in a stable condition, and the dosage of other diseases is not changed during the test.
- eGFR≥30ml / min;
You will not qualify if you...
- Pregnant or lactating women;
- Patients with acute or chronic renal failure (eGFR <30ml / min);
- Patients with severe liver dysfunction (ALT, AST≥70 IU);
- In patients with uncontrolled hypertension, systolic blood pressure ≥160 and / or diastolic blood pressure ≥110mmHg;
- In uncontrolled diabetic patients, fasting blood glucose is> 10mmol / L, and / or glycated hemoglobin is ≥9%;
- Patients that are taking atorvastatin, losartan, amlodipine, fenofibrate, pyrazinamide, tincture diuretics, thiazide diuretics, glucocorticoids, immunosuppressive agents and other drugs that affect uric acid excretion Drugs, those taking aspirin at a dose of> 325mg / day;
- Cancer patients
Trial Site Locations
Total: 1 location
1
Department of Nephrolgoy, Shanghai 10th People's Hospital
Shanghai, Shanghai Municipality, China, 200072
Actively Recruiting
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Research Team
A
Ai Peng, Ph.D., M.D.
J
Jiafen Cheng, M.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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