Sex Hormone-specific Cardiovascular Risks in the Gut Microbiome-host Axis - A Longitudinal Cohort Study.

What this Trial Is About

Researchers are investigating how sex hormones affect the gut microbiome and the development of cardiovascular risk factors in healthy transgender individuals. This observational study will follow 200 participants undergoing hormone replacement therapy (HRT) for two years, aiming to understand the relationship between hormone changes, the microbiome, immune system, and cardiovascular disease risk. The study uses advanced scientific methods like omics platforms and systems biology to collect comprehensive data. Participants will be monitored at baseline and at multiple follow-up points, including an optional one-year check, with analyses of gut bacteria, hormone levels, immune markers, and cardiovascular indicators. The study also tracks changes in physical activity, mental health, diet, and quality of life during the two-year period. Participants will undergo regular assessments including microbiome analysis, blood tests, mental health questionnaires, and physical measurements at baseline, 6, 12, 18, and 24 months. Researchers will document hormone therapy details, lifestyle factors, and cardiovascular risk scores over time. The study aims to provide detailed insights into how sex hormones and the gut microbiome interact to influence cardiovascular health in transgender individuals.

Sex-differential Host-microbiome CVD Risk - A Longitudinal Cohort Approach