Actively Recruiting
Short Course Radiotherapy
Led by Abramson Cancer Center at Penn Medicine · Updated on 2026-05-05
15
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single arm prospective pilot trial determining the safety of short-course radiation therapy in pediatric patients with incurable central nervous system malignancies.
CONDITIONS
Official Title
Short Course Radiotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, aged 21 years or below
- Lansky performance status of 40 or higher
- Diagnosis of an incurable malignancy that either originates outside the brain but has spread to one or more brain sites, or originates and recurs within the brain
- Multidisciplinary review with unanimous consensus confirming intracranial relapse or metastasis
- At least one targetable intracranial lesion visible on imaging
- Multidisciplinary consensus recommending palliative intent radiation
- Signed informed consent from patient or caregiver; assent as appropriate for those under 18
- Prior radiation to the planned treatment area is allowed
- Willingness to comply with all study procedures and availability for the entire study duration
You will not qualify if you...
- Radiotherapy intended for cure
- Serious uncontrolled systemic or psychiatric disorders interfering with participation
- Planned treatment with proton radiation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
K
Kelly Clark
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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