Actively Recruiting
Brain Activity During Speech-in-Noise Perception in Autism, Fragile X Syndrome, and Typical Development Ages 15 to 35
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2026-03-19
60
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are investigating how the brain processes speech in noisy environments in individuals with autism, Fragile X Syndrome, and typical development. The study aims to understand which brain areas are active during speech-in-noise perception and how these regions interact. It also explores whether visual cues can help improve hearing in background noise. Participants include people aged 15 to 35 years across different groups matched by age and sex, focusing on differences in brain responses without excluding based on cognitive ability if tasks can be completed. Participants will undergo hearing tests, cognitive and behavioral assessments, and questionnaires about symptoms. Speech-in-noise perception is evaluated using tasks like the Digits-In-Noise test and the Auditory Attention subtest, which minimize verbal demands to include those with cognitive impairments. Brain activity is measured using a neuroimaging cap combining functional Near Infrared Spectroscopy fNIRS and Event Related Potentials ERP while participants listen to speech sounds with and without background noise and visual stimuli. The neuroimaging sessions include both passive and active tasks lasting about 25 minutes. During the study visit, participants will complete hearing measures, cognitive tests, and possibly diagnostic confirmation. They will wear a cap that records brain activity while hearing sounds and viewing non-social videos or visual shapes synchronized with sounds. Data collected include brain signals, video recordings for analysis, and participant responses to behavioral tests. The main outcomes measured are speech reception thresholds, neural activation patterns, sensory and behavioral questionnaires, and cognitive ability scores. Data privacy is maintained with secure storage and limited access. Participation lasts for the study visit and related assessments.
CONDITIONS
Brief Title
Speech-in-noise Perception in Autism and Fragile X
Research Team
E
Elizabeth Smith, PhD
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