Actively Recruiting
Speech-in-noise Perception in Autism and Fragile X
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2026-03-19
60
Participants Needed
1
Research Sites
128 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main question\[s\] it aims to answer are: 1) How does the brain's response to background noise affect a person's ability to understand speech? 2) Can visual cues improve hearing in background noise? Participants will complete the following: * hearing tests * cognitive and behavioral measures * questionnaires about their symptoms * both passive and active hearing tasks while brain activity is recorded with a neuroimaging cap Results will be compared between individuals with autism with and without Fragile X Syndrome as well as individuals without autism.
CONDITIONS
Official Title
Speech-in-noise Perception in Autism and Fragile X
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants aged 15 to 35 years
- Normal hearing with pure tone average (PTA) of 20 dB HL or less
- Corrected vision of 20/20 on Snellen chart
- No history of premature birth before 36 weeks gestation
- Not taking medications known to affect EEG signals
- English is the first language
- Autism group: diagnosis of Autism Spectrum Disorder confirmed by ADOS and developmental history
- Autism + Fragile X group: documented genetic testing confirming full mutation Fragile X Syndrome and Autism diagnosis
- Typically Developing group: no siblings or parents with Autism Spectrum Disorder or Fragile X Syndrome, no current neurological or psychiatric diagnoses, IQ over 75
You will not qualify if you...
- Hearing loss or uncorrected vision loss
- History of premature birth before 36 weeks gestation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cincinnati Children'S Hospital
Cincinnati, Ohio, United States, 45229-3026
Actively Recruiting
Research Team
E
Elizabeth Smith, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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