Actively Recruiting

Phase Not Applicable
Age: 18Years - 25Years
All Genders
NCT06898554

Spinal and Supraspinal Control in Chronic Ankle Instability

Led by Ayca Yagcioglu · Updated on 2025-03-27

30

Participants Needed

2

Research Sites

36 weeks

Total Duration

On this page

Sponsors

A

Ayca Yagcioglu

Lead Sponsor

Y

Yeditepe University

Collaborating Sponsor

AI-Summary

What this Trial Is About

Ankle sprains are common sports injuries that often lead to chronic ankle instability (CAI). Patients with CAI experience deficits in neuromuscular control (NMC), including proprioception and strength. It is believed that damage to the ankle's ligament mechanoreceptors and the peroneal nerve after the initial ankle sprain can cause alterations in NMC, resulting in postural control and dynamic joint stability dysfunction. Inflammation related to recurrent ankle sprains may also contribute to neuromuscular impairments. Evidence suggests that bilateral postural control deficits occur after an ankle sprain, suggesting alterations in the central nervous system (CNS). Rehabilitation for CAI has been shown to lead to bilateral improvements in NMC, potentially due to neural alterations at both the spinal and supraspinal levels. Cross-education, which refers to the muscular crossed effect of unilateral training, has also been proposed as a mechanism for improving contralateral strength in neurologically healthy individuals. While the exact mechanisms underlying cross-education are not yet fully understood, evidence suggests that it involves neural adaptations at both spinal and supraspinal levels. This study aims to investigate the cross-education effect of a 6-week, unilateral balance training on corticomotor excitability, motor neuron pool excitability, and static and dynamic balance in athletes with chronic ankle instability.

CONDITIONS

Official Title

Spinal and Supraspinal Control in Chronic Ankle Instability

Who Can Participate

Age: 18Years - 25Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Volunteering to participate in the study
  • Being an athlete between the ages of 18-25
  • Playing a field team sport such as basketball, volleyball, or handball
  • Having a history of at least 2 significant grade II lateral ankle sprains diagnosed by a physician
  • Experiencing related inflammatory symptoms and "giving away" sensation
  • Scoring 25 or less on the Cumberland Ankle Instability Tool (CAIT)
  • Scoring below 90% for activities of daily living and below 80% for sports on the Foot and Ankle Ability Measure
  • Having recurrent episodes of lateral ankle sprain on the injured ankle within at least 12 months
Not Eligible

You will not qualify if you...

  • Having an acute injury to lower extremity musculoskeletal structures in the last three months
  • Having had orthopedic surgery on any lower extremity
  • Having bilateral ankle instability
  • Having vestibular or balance disorders

AI-Screening

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Trial Site Locations

Total: 2 locations

1

Yeditepe University Koşuyolu Hospital

Istanbul, Turkey (Türkiye), 34718

Actively Recruiting

2

Yeditepe University

Istanbul, Turkey (Türkiye), 34755

Actively Recruiting

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Research Team

A

Ayca Yagcioglu, MSc

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

3

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