Studying Long-Term Effects and Treatment of Concussions in Adults Aged 60 and Older Using NeuroTracker and Brain Biomarkers

What this Trial Is About

This research aims to better understand the long-term effects of mild traumatic brain injuries concussions in adults aged 60 and older. It focuses on how concussions may increase the risk of dementia and cause lasting changes in brain function and structure. The study compares older adults with and without concussion histories, exploring gender differences and seeking markers that indicate cognitive changes. It also evaluates a cognitive training tool called NeuroTracker as a possible intervention to improve brain health after concussion. Participants will either receive bi-weekly NeuroTracker training sessions for six months or continue their usual activities without this training. NeuroTracker is an online, software-based program that involves visual tracking exercises using 3D glasses, designed to stimulate multiple brain functions simultaneously. Assessments include detailed neuropsychological tests, blood biomarker analyses, and advanced brain imaging diffusion tensor imaging. These evaluations occur at baseline, immediately after the intervention, and again six months later to track changes over time. During the study, participants undergo interviews, cognitive testing, brain scans, and blood draws to collect data on brain structure, function, and inflammation. Researchers will measure cognitive performance and biomarker changes to assess the impact of concussion history and the effectiveness of NeuroTracker training. The study will last about two years for each participant, with ongoing monitoring and follow-up sessions to observe long-term cognitive trajectories and potential improvements.

Spotting and Managing Adult Repeated Traumas in the Brain