Could Neurotracker be used as a clinical marker of recovery following pediatric mild traumatic brain injury? An exploratory study.
Laurie-Ann Corbin-Berrigan, Kristina Kowalski, Jocelyn Faubert...
https://pubmed.ncbi.nlm.nih.gov/32013583Actively Recruiting
Phase Not Applicable
Age: 60Years +
All Genders
Healthy Volunteers
ID07025317
Developing an Evidence-based Approach to Diagnose and Treat Adults With a History of Concussion
Led by Université de Montréal · Updated on 2025-07-20
200
Participants Needed
3
Research Sites
84 weeks
Total Duration
On this page
Sponsors
U
Université de Montréal
Lead Sponsor
U
University of Victoria
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to better understand the long-term effects of mild traumatic brain injuries (concussions) in adults aged 60 and older. It focuses on how concussions may increase the risk of dementia and cause lasting changes in brain function and structure. The study compares older adults with and without concussion histories, exploring gender differences and seeking markers that indicate cognitive changes. It also evaluates a cognitive training tool called NeuroTracker as a possible intervention to improve brain health after concussion. Participants will either receive bi-weekly NeuroTracker training sessions for six months or continue their usual activities without this training. NeuroTracker is an online, software-based program that involves visual tracking exercises using 3D glasses, designed to stimulate multiple brain functions simultaneously. Assessments include detailed neuropsychological tests, blood biomarker analyses, and advanced brain imaging (diffusion tensor imaging). These evaluations occur at baseline, immediately after the intervention, and again six months later to track changes over time. During the study, participants undergo interviews, cognitive testing, brain scans, and blood draws to collect data on brain structure, function, and inflammation. Researchers will measure cognitive performance and biomarker changes to assess the impact of concussion history and the effectiveness of NeuroTracker training. The study will last about two years for each participant, with ongoing monitoring and follow-up sessions to observe long-term cognitive trajectories and potential improvements.
CONDITIONS
Brief Title
Spotting and Managing Adult Repeated Traumas in the Brain
Who Can Participate
Age: 60Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Adults aged 60 years or older
- History of concussion with the most recent injury at least one year prior to the study
- Able to participate in interviews about concussion history, education, occupation, and medical background
- Willing to undergo cognitive assessments, brain imaging, and blood sample collection
You will not qualify if you...
- Diagnosed neurological disorders such as Mild Cognitive Impairment, Alzheimer's disease, or Parkinson's disease
- History of severe psychiatric disorders like schizophrenia
- Use of medications or presence of conditions that may affect cognition, including psychotropic or anticholinergic drugs
- Diagnosed severe visual impairments including color blindness, monocular vision, or blindness
- Contraindications for MRI such as metal implants
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 to 2 visits (virtual or in-person) for eligibility interview and consent process
Baseline Assessment
Duration - Up to several weeks depending on scheduling
Participants complete comprehensive neuropsychological and NeuroTracker assessments, brain imaging (diffusion tensor imaging), and blood sample collection to establish initial cognitive and biomarker status.
1 to 2 visits (in-person) for assessments, imaging, and blood collection
Intervention
Duration - 6 months
Participants undergo a 6-month bi-weekly cognitive training with NeuroTracker or continue activities as normal, to evaluate the effects on cognitive function and brain health.
Twice-weekly 30-minute training sessions conducted remotely from home
Post-intervention and 6-Month Follow-up
Duration - 6 months post-intervention follow-up period
Participants repeat the baseline assessments including neuropsychological testing, NeuroTracker session, brain imaging, and blood collection immediately after the intervention and again 6 months later to monitor changes over time.
2 visits (in-person) for post-intervention and 6-month follow-up assessments
Trial Site Locations
Total: 3 locations
1
Christie Lab
Victoria, British Columbia, Canada, V8N 4V3
Actively Recruiting
2
Jodie Gawryluk
Victoria, British Columbia, Canada, V8N 4V3
Actively Recruiting
3
Faubert Lab
Montreal, Quebec, Canada, H3T 1P1
Actively Recruiting
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Research Team
E
Eduardo Lugo Project Manager, PhD
B
Brian Christie Co-Investigator, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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Published Research Related To This Trial
Multiple Object Tracking Scores Predict Post-Concussion Status Years after Mild Traumatic Brain Injury.
Melanie R Lysenko-Martin, Craig P Hutton, Taya Sparks...
https://pubmed.ncbi.nlm.nih.gov/31950862Tracking multiple targets with multifocal attention.
Patrick Cavanagh, George A Alvarez
https://pubmed.ncbi.nlm.nih.gov/15953754A systematic review of potential long-term effects of sport-related concussion.
Geoff Manley, Andrew J Gardner, Kathryn J Schneider...
https://pubmed.ncbi.nlm.nih.gov/28455362A Protocol for Remote Cognitive Training Developed for Use in Clinical Populations During the COVID-19 Pandemic.
Taylor Snowden, Lisa Ohlhauser, Jamie Morrison...
https://pubmed.ncbi.nlm.nih.gov/37645472