Actively Recruiting
Staphylococcus Aureus Network Adaptive Platform Trial
Led by University of Melbourne · Updated on 2026-05-06
8000
Participants Needed
161
Research Sites
354 weeks
Total Duration
On this page
Sponsors
U
University of Melbourne
Lead Sponsor
B
Berry Consultants
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Staphylococcus aureus Network Adaptive Platform (SNAP) trial is an International Multi-Centered Randomised Adaptive Platform Clinical Trial to evaluate a range of interventions to reduce mortality for patients with Staphylococcus Aureus bacteraemia (SAB).
CONDITIONS
Official Title
Staphylococcus Aureus Network Adaptive Platform Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Staphylococcus aureus complex grown from at least one blood culture
- Admitted to a participating hospital at the time of eligibility assessment or admitted anytime from blood culture collection until assessment if deceased
- For adjunctive treatment domain: Eligible for platform and regardless of clindamycin susceptibility
- For PSSA treatment domain: Penicillin-susceptible Staphylococcus aureus isolated as per defined testing criteria
- For MSSA treatment domain: Methicillin-susceptible Staphylococcus aureus isolated
- For MRSA treatment domain: MRSA confirmed microbiologically
- For early oral switch domain: Clearance of SAB by blood cultures at specified days, afebrile, source control achieved, no evidence of metastatic foci
- For PET/CT domain: Patient accessible for PET/CT at participating site
You will not qualify if you...
- More than 72 hours since index blood culture collection at time of platform entry
- Polymicrobial bacteraemia involving more than one organism (excluding contaminants)
- Previous participation in randomised SNAP platform
- Positive blood culture for same S. aureus strain between 72 hours and 180 days prior
- Treating team advises against enrolment or if death is imminent
- Patient for end-of-life care without appropriate antibiotic treatment
- Age under 18 years where paediatric recruitment is not approved
- Patient deceased since index blood culture collection
- Allergy or hypersensitivity reactions to study antibiotics per domain criteria
- Current severe diarrhoea or C. difficile associated diarrhoea
- Currently receiving antibiotics that cannot be stopped or substituted
- Presence of prosthetic cardiac devices, intravascular clots, or intracardiac infections for early oral switch domain
- Pregnancy, breastfeeding, recent PET/CT, clinical instability, or contraindications for PET/CT domain
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 161 locations
1
Houston Methodist Research Institute
Houston, Texas, United States, 77030
Actively Recruiting
2
Canberra Hospital
Garran, Australia Capital Territory, Australia, 2605
Actively Recruiting
3
Blacktown Hospital
Blacktown, New South Wales, Australia, 2148
Actively Recruiting
4
Royal Prince Alfred Hospital
Camperdown, New South Wales, Australia, 2050
Actively Recruiting
5
Concord Repatriation and General Hospital
Concord, New South Wales, Australia, 2139
Actively Recruiting
6
St Vincent's Hospital Sydney
Darlinghurst, New South Wales, Australia, 2010
Actively Recruiting
7
Nepean Hospital
Kingswood, New South Wales, Australia, 2747
Actively Recruiting
8
St George Hospital
Kogarah, New South Wales, Australia, 2217
Not Yet Recruiting
9
Liverpool Hospital
Liverpool, New South Wales, Australia, 2170
Actively Recruiting
10
John Hunter Hospital
New Lambton Heights, New South Wales, Australia, 2305
Actively Recruiting
11
John Hunter Children's Hospital
Newcastle, New South Wales, Australia, 2305
Actively Recruiting
12
Orange Health Service
Orange, New South Wales, Australia, 2800
Actively Recruiting
13
Prince of Wales Hospital
Randwick, New South Wales, Australia, 2031
Actively Recruiting
14
Sydney Children's Hospital
Randwick, New South Wales, Australia, 2031
Actively Recruiting
15
The Children's Hospital at Westmead
Westmead, New South Wales, Australia, 2145
Actively Recruiting
16
Westmead Hospital
Westmead, New South Wales, Australia, 2145
Actively Recruiting
17
Wollongong Hospital
Wollongong, New South Wales, Australia, 2500
Actively Recruiting
18
Royal Darwin Hospital
Tiwi, Northern Territory, Australia, 0811
Actively Recruiting
19
Sunshine Coast University Hospital
Birtinya, Queensland, Australia, 4575
Actively Recruiting
20
Cairns Hospital
Cairns, Queensland, Australia, 4870
Actively Recruiting
21
Royal Brisbane and Women's Hospital
Herston, Queensland, Australia, 4029
Actively Recruiting
22
Ipswich Hospital
Ipswich, Queensland, Australia, 4305
Actively Recruiting
23
Logan Hospital
Meadowbrook, Queensland, Australia, 4131
Not Yet Recruiting
24
Redcliffe Hospital
Redcliffe, Queensland, Australia, 4020
Actively Recruiting
25
Robina Hospital
Robina, Queensland, Australia, 4226
Actively Recruiting
26
Queensland Children's Hospital
South Brisbane, Queensland, Australia, 4101
Actively Recruiting
27
Gold Coast University Hospital
Southport, Queensland, Australia, 4215
Actively Recruiting
28
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia, 4102
Not Yet Recruiting
29
Lyell McEwin Hospital
Adelaide, South Australia, Australia, 5112
Actively Recruiting
30
Flinders Medical Centre
Bedford Park, South Australia, Australia, 5042
Actively Recruiting
31
Women and Children's Hospital
North Adelaide, South Australia, Australia, 5006
Not Yet Recruiting
32
Women's and Children's Hospital
North Adelaide, South Australia, Australia, 5006
Not Yet Recruiting
33
Royal Hobart Hospital
Hobart, Tasmania, Australia, 7000
Not Yet Recruiting
34
Launceston Hospital
Launceston, Tasmania, Australia, 7250
Actively Recruiting
35
Grampians Health
Ballarat, Victoria, Australia, 3350
Actively Recruiting
36
Bendigo Health
Bendigo, Victoria, Australia, 3550
Actively Recruiting
37
Box Hill Hospital
Box Hill, Victoria, Australia, 3128
Actively Recruiting
38
Monash Children's Hospital
Clayton, Victoria, Australia, 3168
Not Yet Recruiting
39
Monash Health - Monash Medical Centre & Jesse McPherson Private Hospital
Clayton, Victoria, Australia, 3168
Actively Recruiting
40
Western Health - Footscray, Joan Kirner & Sunshine Hospitals
Footscray, Victoria, Australia, 3011
Actively Recruiting
41
Frankston Hospital
Frankston, Victoria, Australia, 3199
Not Yet Recruiting
42
Barwon Health - University Hospital Geelong
Geelong, Victoria, Australia, 3220
Actively Recruiting
43
Austin Hospital
Heidelberg, Victoria, Australia, 3084
Actively Recruiting
44
Alfred Hospital
Melbourne, Victoria, Australia, 3004
Actively Recruiting
45
Royal Melbourne Hospital
Parkville, Victoria, Australia, 3050
Actively Recruiting
46
Royal Children's Hospital Melbourne
Parkville, Victoria, Australia, 3052
Actively Recruiting
47
Goulburn Valley Health
Shepparton, Victoria, Australia, 3630
Completed
48
La Trobe Regional Hospital
Traralgon, Victoria, Australia, 3844
Not Yet Recruiting
49
Fiona Stanley Hospital
Murdoch, Western Australia, Australia, 6150
Actively Recruiting
50
Perth Children's Hospital
Nedlands, Western Australia, Australia, 6009
Actively Recruiting
51
Royal Perth Hospital
Perth, Western Australia, Australia, 6000
Actively Recruiting
52
Armadale Hospital
Perth, Western Australia, Australia, 6112
Actively Recruiting
53
Peter Lougheed Centre
Calgary, Alberta, Canada, T1Y 6J4
Actively Recruiting
54
Foothills Medical Center
Calgary, Alberta, Canada, T2N4Z6
Actively Recruiting
55
Rockyview Hospital
Calgary, Alberta, Canada, T2V 1P9
Actively Recruiting
56
South Health Campus
Calgary, Alberta, Canada, T3M 1M4
Actively Recruiting
57
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G2B7
Actively Recruiting
58
Richmond Hospital
Richmond, British Columbia, Canada, V6X1A2
Actively Recruiting
59
Fraser Health Authority - Surrey Memorial Hospital
Surrey, British Columbia, Canada
Actively Recruiting
60
Vancouver General Hospital
Vancouver, British Columbia, Canada, V5Z1M9
Actively Recruiting
61
St. Boniface Hospital
Winnipeg, Manitoba, Canada, R2H 2A6
Actively Recruiting
62
Health Sciences Centre Winnipeg
Winnipeg, Manitoba, Canada, R3A1R9
Actively Recruiting
63
Grace Hospital
Winnipeg, Manitoba, Canada, R3J 3M7
Actively Recruiting
64
Eastern Health - Health Sciences Centre (Memorial University)
St. John's, Newfoundland and Labrador, Canada, A1B3V6
Actively Recruiting
65
Eastern Regional Health Authority - St. Clare's Mercy Hospital
St. John's, Newfoundland and Labrador, Canada
Actively Recruiting
66
Toronto East Health Network - Michael Garron Hospital
East York, Ontario, Canada, M4C3E7
Actively Recruiting
67
University Health Network - Toronto General Hospital
East York, Ontario, Canada, M5G2C4
Completed
68
Hamilton Health Sciences - Hamilton General Hospital
Hamilton, Ontario, Canada, L8P1A2
Actively Recruiting
69
Hamilton Health Sciences - Juravinski Hospital
Hamilton, Ontario, Canada
Actively Recruiting
70
Kingston Health Sciences Centre - Kingston General Hospital
Kingston, Ontario, Canada, K7L2V7
Actively Recruiting
71
London Health Sciences Centre - University Hospital, LHSC
London, Ontario, Canada
Completed
72
Niagara Health - Niagara Falls Site
Niagara Falls, Ontario, Canada
Actively Recruiting
73
The Ottawa Hospital - Civic Campus
Ottawa, Ontario, Canada, K1H8L6
Actively Recruiting
74
The Ottawa Hospital - General Campus
Ottawa, Ontario, Canada
Actively Recruiting
75
Sault Area Hospital
Sault Ste. Marie, Ontario, Canada, P6B 0A8
Completed
76
Niagara Health - St. Catharines Site
St. Catharines, Ontario, Canada, L2S 0A9
Actively Recruiting
77
Unity Health - St Michael's Hospital
Toronto, Ontario, Canada, M1L 1W1
Actively Recruiting
78
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N3M5
Actively Recruiting
79
Sinai Heath System - Mount Sinai Hospital
Toronto, Ontario, Canada, M5G1X5
Actively Recruiting
80
Unity Health Toronto - St Joseph's Health Centre
Toronto, Ontario, Canada
Actively Recruiting
81
University Health Network - Toronto Western Hospital
Toronto, Ontario, Canada
Completed
82
CISSS - Hôpital Cité-de-la-Santé Hospital
Laval, Quebec, Canada
Actively Recruiting
83
Jewish General Hospital
Montreal, Quebec, Canada, H3T1E2
Actively Recruiting
84
McGill University Health Centre - Montral General Hospital
Montreal, Quebec, Canada, H4A3J1
Actively Recruiting
85
McGill University Health Centre - Montreal Children's Hospital
Montreal, Quebec, Canada
Not Yet Recruiting
86
McGill University Health Centre - Royal Victoria Hospital
Montreal, Quebec, Canada
Actively Recruiting
87
Hôpital Régional de Saint Jérôme
Saint-Jérôme, Quebec, Canada, J7Z5T3
Actively Recruiting
88
University of Sherbrooke Health Centre - Hospital Fleurimont
Sherbrooke, Quebec, Canada, J1H 5H3
Actively Recruiting
89
University of Sherbrooke Health Centre - Hotel Dieu
Sherbrooke, Quebec, Canada
Actively Recruiting
90
CHU de Rennes - Hôpital Pontchaillou
Rennes, France
Actively Recruiting
91
Charité University Hospital Berlin
Berlin, Germany
Actively Recruiting
92
University Hospital Carl Gustav Carus Dresden
Dresden, Germany
Actively Recruiting
93
University Medical Centre Freiburg
Freiburg im Breisgau, Germany
Actively Recruiting
94
Otto-von-Guericke-university Magdeburg
Magdeburg, Germany
Actively Recruiting
95
Rambam Health Care Campus
Haifa, Israel, 310960
Actively Recruiting
96
Beilinson Hospital
Petah Tikva, Israel, 49100
Actively Recruiting
97
Schneider Hospital
Petah Tikva, Israel
Actively Recruiting
98
Sheba Medical Centre
Ramat Gan, Israel, 49100
Actively Recruiting
99
Science Tokyo University Hospital
Ichikawa, Chiba, Japan, 272-0827
Actively Recruiting
100
Jeroen Bosch Hospital
's-Hertogenbosch, Netherlands
Actively Recruiting
101
Rijnstate Hospital
Arnhem, Netherlands
Active, Not Recruiting
102
Treant Ziekenhuis
Emmen, Netherlands
Actively Recruiting
103
UMC Groningen
Groningen, Netherlands
Active, Not Recruiting
104
Maastricht UMC+
Maastricht, Netherlands
Actively Recruiting
105
Antonius Ziekenhuis
Nieuwegein, Netherlands
Actively Recruiting
106
Radboud University Medical Center
Nijmegen, Netherlands
Actively Recruiting
107
Ikazia Ziekenhuis
Rotterdam, Netherlands
Actively Recruiting
108
University Medical Center Utrecht
Utrecht, Netherlands
Actively Recruiting
109
Auckland City Hospital
Grafton, Auckland, New Zealand, 1023
Actively Recruiting
110
Middlemore Hospital
Otahuhu, Auckland, New Zealand, 1640
Actively Recruiting
111
North Shore Hospital
Takapuna, Auckland, New Zealand, 0620
Actively Recruiting
112
Christchurch Hospital
Christchurch, Canterbury, New Zealand, 8011
Not Yet Recruiting
113
Hutt Valley Hospital
Boulcott, Lower Hutt, New Zealand, 5010
Actively Recruiting
114
Wellington Hospital
Newtown, Wellington Region, New Zealand, 6021
Actively Recruiting
115
Starship Hospital
Auckland, New Zealand, 1023
Actively Recruiting
116
KidzFirst
Auckland, New Zealand, 2025
Actively Recruiting
117
Waikato Hospital
Hamilton, New Zealand, 3240
Actively Recruiting
118
Tauranga Hospital
Tauranga, New Zealand, 3112
Actively Recruiting
119
Whangarei Hospital
Whangarei, New Zealand, 0148
Not Yet Recruiting
120
National University Hospital
Singapore, Singapore, 119228
Actively Recruiting
121
Singapore General Hospital
Singapore, Singapore, 168753
Actively Recruiting
122
Tan Tock Seng Hospital
Singapore, Singapore, 308433
Actively Recruiting
123
Charlotte Maxeke Johannesburg Academic Hospital
Johannesburg, South Africa
Not Yet Recruiting
124
Helen Joseph Hospital
Johannesburg, South Africa
Active, Not Recruiting
125
Rahima Moosa Mother and Child Hospital
Johannesburg, South Africa
Not Yet Recruiting
126
Helsingborg Hospital
Helsingborg, Sweden
Actively Recruiting
127
SUS Malmö
Malmö, Sweden
Actively Recruiting
128
NHS Grampian
Aberdeen, United Kingdom
Not Yet Recruiting
129
University Hospitals Birmingham
Birmingham, United Kingdom
Actively Recruiting
130
Brighton and Sussex University Hospitals
Brighton, United Kingdom
Actively Recruiting
131
North Bristol
Bristol, United Kingdom
Actively Recruiting
132
University Hospitals Bristol and Weston
Bristol, United Kingdom
Actively Recruiting
133
Cambridge University Hospitals
Cambridge, United Kingdom
Not Yet Recruiting
134
Cardiff and Vale University
Cardiff, United Kingdom
Actively Recruiting
135
Royal Cornwall Hospitals
Cornwall, United Kingdom
Not Yet Recruiting
136
Royal Devon University Healthcare
Devon, United Kingdom
Not Yet Recruiting
137
NHS Tayside
Dundee, United Kingdom
Not Yet Recruiting
138
Lothian Western General
Edinburgh, United Kingdom
Actively Recruiting
139
Greater Glasgow and Clyde
Glasgow, United Kingdom
Not Yet Recruiting
140
NHS Golden Jubilee
Glasgow, United Kingdom
Not Yet Recruiting
141
Hull University Teaching Hospitals
Hull, United Kingdom
Actively Recruiting
142
Leeds Teaching Hospitals
Leeds, United Kingdom
Actively Recruiting
143
Liverpool University Hospital
Liverpool, United Kingdom
Actively Recruiting
144
Barts Health
London, United Kingdom
Actively Recruiting
145
Great Ormond Street
London, United Kingdom
Not Yet Recruiting
146
Guys and St Thomas'
London, United Kingdom
Actively Recruiting
147
Imperial College Healthcare
London, United Kingdom
Actively Recruiting
148
Kings College Hospital
London, United Kingdom
Not Yet Recruiting
149
Royal Free London
London, United Kingdom
Actively Recruiting
150
University College London Hospitals
London, United Kingdom
Actively Recruiting
151
Whittington Health
London, United Kingdom
Actively Recruiting
152
Manchester University Hospitals
Manchester, United Kingdom
Actively Recruiting
153
Newcastle Upon Tyne Hospitals
Newcastle upon Tyne, United Kingdom
Actively Recruiting
154
Nottingham University Hospitals
Nottingham, United Kingdom
Not Yet Recruiting
155
Oxford University Hospitals
Oxford, United Kingdom
Actively Recruiting
156
Sheffield Teaching Hospitals
Sheffield, United Kingdom
Not Yet Recruiting
157
South Tees Hospitals
South Tees, United Kingdom
Actively Recruiting
158
University Hospital Southampton
Southampton, United Kingdom
Actively Recruiting
159
NHS Forth Valley
Stirling, United Kingdom
Not Yet Recruiting
160
University Hospitals of North Midlands
Stoke, United Kingdom
Not Yet Recruiting
161
Swansea Bay University Health Board
Swansea, United Kingdom
Actively Recruiting
Research Team
L
Lauren Barina
CONTACT
S
Susan Goulding
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
12
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