The STEREO-DBS Study: 7-Tesla MRI Brain Network Analysis for Deep Brain Stimulation

What this Trial Is About

Researchers are evaluating the use of 7-Tesla magnetic resonance imaging (7T MRI) brain network analysis to improve deep brain stimulation (DBS) treatment for patients with advanced Parkinson's disease. DBS targets the subthalamic nucleus (STN) to modulate malfunctioning brain networks and improve motor symptoms. Current imaging methods using lower resolution MRIs limit the ability to visualize brain networks effectively, leading to variable treatment benefits. The study aims to see if 7T MRI can better visualize STN connections and electrode placement to enhance motor symptom improvement measured by the Unified Parkinson's Disease Rating Scale (UPDRS-III). This is a prospective observational study using 7T MRI as part of standard care without additional interventions. The 7T MRI will visualize the STN subdivisions and their cortical projections, including motor, associative, and limbic areas. Researchers will analyze the position of DBS electrodes relative to these projections and correlate electrode placement with motor symptom improvements. The study collects data continuously from April 2022 to April 2033 as part of routine clinical follow-up. Participants will undergo 7T MRI scanning, which is non-invasive and involves no pain, with monitoring and safety measures in place. Researchers will assess motor symptoms using UPDRS-III after six months of DBS, along with secondary measures including functional health, quality of life, apathy, treatment satisfaction, operation and hospitalization times, medication changes, side effects, and complications. The study involves minimal risk and uses data already collected in routine care, with ongoing monitoring throughout the study period.

The STEREO-DBS Study: 7-Tesla MRI Brain Network Analysis for Deep Brain Stimulation