Stroke Volume-Guided Fluid Treatment Compared to Moderate Weight-Based Fluid Resuscitation for Adults with Moderate to Severe Acute Pancreatitis

What this Trial Is About

Researchers are evaluating a fluid resuscitation method based on stroke volume changes in adults with moderate to severe acute pancreatitis. This trial aims to address the current challenge where aggressive hydration used in inpatient care can cause fluid overload without improving outcomes. It follows findings from the WATERFALL study, which showed moderate hydration may be safer and more effective than aggressive hydration. The study compares two approaches one group receives Lactated Ringers solution dosed according to individual changes in stroke volume during a leg raise maneuver, while the other group receives moderate fluid resuscitation based on body weight. This is a randomized controlled trial enrolling adults aged 18 to 75 with predicted moderate to severe acute pancreatitis. The fluid treatment is administered during the inpatient period with careful monitoring. Participants will be closely observed from enrollment up to 30 days following. Researchers monitor systemic inflammatory response syndrome SIRS values at 48 hours, pancreatitis activity scores, clinical complications, and various blood biomarkers including C-reactive protein and interleukins. The study assesses participant condition during their hospital stay and measures inflammation and fluid overload risks. Safety and clinical outcomes are evaluated throughout the treatment and follow-up period.

Stroke Volume-based Fluid Resuscitation in AP