Study on Blood Pressure Variability and Frailty in Older Adults with Hypertension: the HypoPHrail Study

What this Trial Is About

This research aims to study blood pressure variability and frailty in older adults who have hypertension. It focuses on whether a hypotensive phenotype, defined by specific low daytime systolic blood pressure episodes detected through ambulatory blood pressure monitoring, is linked to adverse events such as death, hospitalization, falls, uncontrolled hypertension emergencies, or major cardiovascular events. This observational, prospective, single-center study is conducted by Istituto Auxologico Italiano and is non-profit in nature. Participants are assessed using diagnostic tests and questionnaires that measure office blood pressure, orthostatic hypotension, 24-hour ambulatory blood pressure, and frailty using several assessment tools. The study also examines the relationship between home blood pressure variability and frailty, as well as short-term blood pressure variability and adverse events. The prevalence of the hypotensive phenotype in hypertensive individuals according to frailty status is also determined. During the study, participants will undergo blood pressure monitoring and frailty assessments. Researchers will track the incidence of adverse events over a 24-month follow-up period and assess the prevalence of the hypotensive phenotype at the start of the study. The total participation duration includes baseline assessments and follow-up to observe outcomes related to blood pressure variability and frailty in older adults with hypertension.

Study on Blood Pressure Variability and Frailty in the Older People