Actively Recruiting
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
Led by Revolution Medicines, Inc. · Updated on 2026-03-12
420
Participants Needed
129
Research Sites
290 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to docetaxel.
CONDITIONS
Official Title
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 18 years old and has provided informed consent
- Eastern Cooperative Oncology Group performance status of 0 or 1
- Confirmed diagnosis of locally advanced or metastatic NSCLC not suitable for curative surgery or radiotherapy
- Measurable disease according to RECIST v1.1 criteria
- Adequate bone marrow, liver, kidney, and coagulation function
- Received one to two prior treatments including anti-PD-1/anti-PD-L1 therapy and platinum chemotherapy
- Documented nonsynonymous RAS mutation in KRAS, NRAS, or HRAS at codons 12, 13, or 61
- Able to take oral medications
You will not qualify if you...
- Prior treatment with direct RAS-targeted therapy or docetaxel
- Untreated central nervous system metastases
- Significant cardiovascular disease, lung disease, or impaired gastrointestinal function
- Currently receiving other anticancer therapy
- Pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 129 locations
1
Alabama Oncology
Birmingham, Alabama, United States, 35243
Actively Recruiting
2
MemorialCare Long Beach Medical Center
Long Beach, California, United States, 90806
Actively Recruiting
3
Yale University, Smillow Cancer Center
New Haven, Connecticut, United States, 06519
Actively Recruiting
4
Florida Cancer Specialists & Research Institute - South
Fort Myers, Florida, United States, 33901
Actively Recruiting
5
BRCR Global
Plantation, Florida, United States, 33322
Actively Recruiting
6
Cancer Care Centers of Breevard
Rockledge, Florida, United States, 32955
Actively Recruiting
7
Florida Cancer Specialists & Research Institute - North
St. Petersburg, Florida, United States, 33705
Actively Recruiting
8
Cleveland Clinic Martin North
Stuart, Florida, United States, 34994
Actively Recruiting
9
Florida Cancer Specialists & Research Institute - East
West Palm Beach, Florida, United States, 33401
Actively Recruiting
10
University Cancer and Blood Center
Athens, Georgia, United States, 30607
Actively Recruiting
11
Center for Care and Discovery
Chicago, Illinois, United States, 60637
Actively Recruiting
12
The University of Kansas Cancer Center
Westwood, Kansas, United States, 66205
Actively Recruiting
13
Johns Hopkins University of Medicine
Baltimore, Maryland, United States, 21224
Actively Recruiting
14
Karmanos Cancer Institute
Detroit, Michigan, United States, 48201
Actively Recruiting
15
Henry Ford Health
Detroit, Michigan, United States, 48202
Actively Recruiting
16
Washington University School of Medicine - Siteman Cancer Center
St Louis, Missouri, United States, 63110
Actively Recruiting
17
St. Vincent Frontier Cancer Center
Billings, Montana, United States, 59102
Actively Recruiting
18
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
19
Morristown Medical Center (MMCORC)
Morristown, New Jersey, United States, 07960
Actively Recruiting
20
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
Actively Recruiting
21
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
22
Montefiore Medical Center
The Bronx, New York, United States, 10461
Actively Recruiting
23
UNC Lineberger Comprehensive Cancer Center at University of North Carolina
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
24
TriHealth Cancer & Blood Institute Research
Cincinnati, Ohio, United States, 45220
Actively Recruiting
25
Taylor Cancer Research Center
Maumee, Ohio, United States, 43537
Actively Recruiting
26
Oncology Associates of Oregon PC
Eugene, Oregon, United States, 97401
Actively Recruiting
27
Avera Cancer Institute
Sioux Falls, South Dakota, United States, 57105
Actively Recruiting
28
SCRI Oncology Partners - Tennessee
Nashville, Tennessee, United States, 37203
Actively Recruiting
29
Texas Oncology - South Austin
Austin, Texas, United States, 78745
Actively Recruiting
30
Texas Oncology Dallas
Dallas, Texas, United States, 75251
Actively Recruiting
31
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
32
Texas Oncology - Gulf Coast
The Woodlands, Texas, United States, 77380
Actively Recruiting
33
Utah Cancer Specialists
Salt Lake City, Utah, United States, 84106
Actively Recruiting
34
Virginia Cancer Specialists
Fairfax, Virginia, United States, 22031
Actively Recruiting
35
Blacktown Medical Oncology Research
Blacktown, New South Wales, Australia, 2148
Actively Recruiting
36
Chris O'Brien Lifehouse
Camperdown, New South Wales, Australia, 2050
Actively Recruiting
37
Calvary Mater Newcastle
Waratah, New South Wales, Australia, 2298
Actively Recruiting
38
Mater Misericordiae Limited
South Brisbane, Queensland, Australia, 4101
Actively Recruiting
39
The Alfred Hospital
Melbourne, Victoria, Australia, 3004
Actively Recruiting
40
Sir Charles Gairdner Hospital
Perth, Western Australia, Australia, 6009
Actively Recruiting
41
Institut Jules Bordet
Anderlecht, Belgium, Belgium, 1070
Actively Recruiting
42
Grand Hôpital de Charleroi - Les Viviers
Gilly, Belgium, 6060
Actively Recruiting
43
AZ Groeninge
Kortrijk, Belgium, 8500
Actively Recruiting
44
UZ Leuven-Campus Gasthuisberg
Leuven, Belgium, 3000
Actively Recruiting
45
AZ Delta
Roeselare, Belgium, 8800
Actively Recruiting
46
CHU Strasbourg - Nouvel Hôpital Civil
Strasbourg, Bas Rhin, France, 67091
Actively Recruiting
47
Hopital Nord - CHU Marseille
Marseille, Bouches-du-Rhône, France, 13915
Actively Recruiting
48
Institut régional du Cancer de Montpellier
Montpellier, Herault, France, 34298
Actively Recruiting
49
CHU Rennes Hôpital Pontchaillou
Rennes, Ille et Vilaine, France, 35033
Actively Recruiting
50
CHU de Grenoble - Hôpital Albert Michallon
La Tronche, Isere, France, 38700
Actively Recruiting
51
CHU Nantes - Hôpital Guillaume et René Laënnec
Saint-Herblain, Loire Atlantique, France, 44805
Actively Recruiting
52
Institut de Cancerologie de l Ouest
Saint-Herblain, Loire Atlantique, France, 44805
Actively Recruiting
53
Centre Leon Berard
Léon, Lyon, France, 69008
Actively Recruiting
54
Hopital Albert Calmette - CHU Lille
Lille, Nord, France, 59037
Actively Recruiting
55
Hôpital Bichat - Claude Bernard
Paris, Paris, France, 75018
Actively Recruiting
56
Hopital Louis Pradel
Bron, Rhone, France, 69677
Actively Recruiting
57
Centre Hospitalier Intercommunal de Créteil
Créteil, Val de Marne, France, 94000
Actively Recruiting
58
Institut Gustave Roussy
Vaillant, Villejuif, France, 94800
Actively Recruiting
59
CHU Brest - Hôpital Morvan
Brest, France, 29200
Actively Recruiting
60
Institut Bergonie
Gironde, France, 33076
Actively Recruiting
61
CHU de Toulouse - Hopital Larrey
Toulouse, France, 31059
Actively Recruiting
62
LKI Lungenfachklinik Immenhausen
Immenhausen, Hesse, Germany, 34376
Actively Recruiting
63
Universitaetsklinikum Essen
Essen, North Rhine-Westphalia, Germany, 45147
Actively Recruiting
64
Universitaetsklinikum Carl Gustav Carus TU Dresden
Dresden, Saxony, Germany, 01307
Actively Recruiting
65
Thoraxklinik Heidelberg gGmbH
Baden, Wuerttemberg, Germany, 69469
Actively Recruiting
66
Klinikum Esslingen GmbH
Baden, Germany, 73730
Actively Recruiting
67
Evangelische Lungenklinik Berlin
Berlin, Germany, 13125
Actively Recruiting
68
Hong Kong United Oncology Centre
Hong Kong, Hong Kong
Actively Recruiting
69
Queen Mary Hospital
Hong Kong, Hong Kong
Actively Recruiting
70
Mater Private Hospital
Dublin, Dublin, Ireland, 7
Actively Recruiting
71
University Hospital Limerick
Cork, Limerick, Ireland, V94 F858
Actively Recruiting
72
Beaumont Hospital Cancer Clinical
Dublin, Ireland, D09 V2N0
Actively Recruiting
73
IEO Istituto Europeo di Oncologia
Milan, Milano, Italy, 20141
Actively Recruiting
74
Azienda Socio Sanitaria Territoriale Niguarda
Milan, Milano, Italy, 21206
Actively Recruiting
75
Istituto Clinico Humanitas
Rossano, Milano, Italy, 20089
Actively Recruiting
76
Fondazione IRCCS San Gerardo dei Tintori
Monza, Milan, Italy, 20900
Actively Recruiting
77
Istituto Nazionale Tumori Fondazione G. Pascale
Naples, Napoli, Italy, 80131
Actively Recruiting
78
Azienda Ospedaliero Universitaria Pisana (Presidio di Cisanello)
Pisa, Pisa, Italy, 56124
Actively Recruiting
79
Istituto Nazionale dei Tumori Regina Elena IRCCS
Roma, Roma, Italy, 00144
Actively Recruiting
80
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Italy, 00168
Actively Recruiting
81
Aichi Cancer Center Hospital
Nagoya, Aichi-ken, Japan, 464-8681
Actively Recruiting
82
Fujita Health University Hospital
Toyoake-shi, Aichi-ken, Japan, 470-1192
Actively Recruiting
83
National Cancer Center Hospital East
Kashiwa-shi, Chiba, Japan, 277-8577
Actively Recruiting
84
NHO Shikoku Cancer Center
Matsuyama, Ehime, Japan, 791-0280
Actively Recruiting
85
National Hospital Organization Hokkaido Cancer Center
Sapporo, Hokkaido, Japan, 003-0804
Actively Recruiting
86
Hyogo Cancer Center
Akashi, Hyōgo, Japan, 673-8558
Actively Recruiting
87
Kanazawa University Hospital
Kanazawa, Ishikawa-ken, Japan, 920-8641
Actively Recruiting
88
Kanagawa Cancer Center
Yokohama, Kanagawa, Japan, 241-8515
Actively Recruiting
89
Tohoku University Hospital
Sendai, Miyagi, Japan, 980-8574
Actively Recruiting
90
Nara Medical University Hospital
Kashihara-shi, Nara, Japan, 634-8522
Actively Recruiting
91
Niigata Cancer Center
Niigata, Niigata, Japan, 951-8566
Actively Recruiting
92
Kansai Medical University Hospital
Hirakata-shi, Osaka, Japan, 573-1191
Actively Recruiting
93
Kindai University Hospital
Osakasayama-shi, Osaka, Japan, 589-8511
Actively Recruiting
94
Shizuoka Cancer Center
Nagaizumi-chō, Shizuoka, Japan, 411-8777
Actively Recruiting
95
National Cancer Center Hospital
Chuo Ku, Tokyo, Japan, 104-0045
Actively Recruiting
96
Cancer Institute Hospital of JFCR
Koto-Ku, Tokyo, Japan, 135-8550
Actively Recruiting
97
Wakayama Medical University Hospital
Wakayama, Wakayama, Japan, 641-8510
Actively Recruiting
98
Amsterdam UMC, Locatie VUMC
Amsterdam, Netherlands, Netherlands, 1081BT
Actively Recruiting
99
Erasmus Medisch Centrum
Rotterdam, Netherlands, Netherlands, 3015AA
Actively Recruiting
100
Antoni van Leeuwenhoek
Amsterdam, Netherlands, 1066 CX
Actively Recruiting
101
Maastricht University Medical Center P. Debyelaan 25
Maastricht, Netherlands, 6229
Actively Recruiting
102
Radboudumc
Nijmegen, Netherlands, 6525 GA
Actively Recruiting
103
Auckland City Hospital - Cancer and Blood Research
Grafton, Auckland, New Zealand, 1023
Actively Recruiting
104
INSTYTUT GENETYKI I IMMMUNOLOGII GENIM sp. z o.o.
Lublin, Poland, 29-609
Actively Recruiting
105
Med-Polonia Sp. z o.o.
Poznan, Poland, 60-693
Actively Recruiting
106
Aidport Sp. z o.o.
Skorzewo, Poland, 60-185
Actively Recruiting
107
Pan American Center for Oncology Trials
San Juan, Puerto Rico, Puerto Rico, 00909
Actively Recruiting
108
National University Hospital
Singapore, Singapore, Singapore, 119074
Actively Recruiting
109
National Cancer Centre Singapore
Singapore, Singapore, 168583
Actively Recruiting
110
Ajou University Hospital
Gyeonggi-do, Suwon-si, South Korea, 16499
Actively Recruiting
111
Chungbuk National University Hospital
Cheongju-si, South Korea, 28644
Actively Recruiting
112
Chonnam National University Hwasun Hospital
Hwasun, South Korea, 58128
Actively Recruiting
113
Korea University Anam Hospital
Seoul, South Korea, 02841
Actively Recruiting
114
Severance Hospital, Yonsei University Health System
Seoul, South Korea, 03722
Actively Recruiting
115
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
116
Complejo Hospitalario Universitario A Coruña
A Coruña, A Coruña, Spain, 15006
Actively Recruiting
117
Hospital Universitari Dexeus
Barcelona, Barcelona, Spain, 08028
Actively Recruiting
118
Hospital Universitario La Paz
Fuencarral-El Pardo, Madrid, Spain, 28046
Actively Recruiting
119
Hospital Universitario HM Madrid Sanchinarro
Madrid, Madrid, Spain, 28050
Actively Recruiting
120
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain, 08041
Actively Recruiting
121
Universitätsspital Basel
Basel, Switzerland, 4031
Actively Recruiting
122
HFR Fribourg/Kantonsspital Fribourg
Fribourg, Switzerland, 1708
Actively Recruiting
123
Kantonsspital St. Gallen
Sankt Gallen, Switzerland, 9000
Actively Recruiting
124
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan, Taiwan, 100
Actively Recruiting
125
National Cheng Kung University Hospital
Tainan, Taiwan, Taiwan, 704
Actively Recruiting
126
National Taiwan University Hospital
Taipei, Taiwan, Taiwan, 10002
Actively Recruiting
127
Taipei Medical University Hospital
Taipei, Taiwan, 110
Actively Recruiting
128
Chang Gung Medical Foundation Linkou
Taoyuan, Taiwan, 333
Actively Recruiting
129
The Christie NHS Foundation Trust
Manchester, United Kingdom, M20 4BX
Actively Recruiting
Research Team
R
Revolution Medicines Study Director
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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