Observational Study to Develop a Risk-Based Screening Protocol for Lung Issues in Adults with Rheumatoid Arthritis in Austria

What this Trial Is About

Researchers are studying pleuropulmonary manifestations in patients with rheumatoid arthritis RA to develop a standardized, risk-adapted screening protocol. This study aims to better detect lung and pleural involvement in RA by evaluating a wide range of clinical, functional, and demographic factors. The research includes using machine learning to create a tool that helps assess risk based on these factors. Participants will undergo thorough clinical evaluations by pulmonology and rheumatology specialists, including standardized disease activity and symptom scoring. Laboratory tests such as RF, ACPA, CRP, and CEA will be collected, alongside lung function tests like body plethysmography, TLCO, FeNO, and the six-minute walk test. Ultrasound examinations of the thorax and joints will also be performed. The study plans to use the collected data to develop a machine learning-based risk model, which will be made available as an online tool and mobile app for clinical use. During the study, participants will receive comprehensive clinical and laboratory assessments to collect data on lung involvement. Researchers will measure the number of RA patients with pleuropulmonary manifestations using an AI-supported multiparametric risk profile analysis at baseline. The study is observational, with no treatment interventions, and participants will be closely monitored through these evaluations. The study will continue until September 2029, allowing for thorough data gathering and validation of the screening tool.

Study on the Detection of Pleuropulmonary Manifestations in Rheumatoid Arthritis