Actively Recruiting
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
Led by Children's Oncology Group · Updated on 2026-05-04
240
Participants Needed
109
Research Sites
471 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This phase II trial studies how well lower dose radiotherapy after chemotherapy (Carboplatin \& Etoposide) works in treating children with central nervous system (CNS) germinomas. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. Researchers want to see if lowering the dose of standard radiotherapy (RT) after chemotherapy can help get rid of CNS germinomas with fewer long-term side effects.
CONDITIONS
Official Title
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must be 3 years or older and younger than 30 years at enrollment
- Newly diagnosed primary localized germinoma of the suprasellar and/or pineal region confirmed by pathology or tumor markers
- Patients with bifocal involvement or pineal lesion with diabetes insipidus and specific tumor marker levels
- Patients with germinoma of basal ganglia and/or thalamic sites
- Patients with metastatic germinoma including distant disease in brain, ventricles, or spine
- Patients with germinoma mixed with mature teratoma
- Performance status of 0, 1, or 2 on ECOG, Karnofsky, or Lansky scales
- Eligibility confirmed by rapid central imaging and tumor marker review
- Required MRI scans of brain and spine obtained within specified timeframes
- Protocol therapy must begin within 31 days of diagnosis or surgery
- Lumbar cerebrospinal fluid obtained prior to enrollment unless medically contraindicated
- Blood counts and kidney and liver function tests within set thresholds prior to enrollment
- No severe CNS toxicity (grade 2 or less)
- Patients with controlled seizure disorder on anticonvulsants
- HIV-infected patients on effective therapy with undetectable viral load
You will not qualify if you...
- Presence of malignant pathological elements such as endodermal sinus tumor, embryonal carcinoma, choriocarcinoma, malignant or immature teratoma, or mixed germ cell tumor
- Only mature teratoma present without tumor markers
- Prior tumor-directed therapy other than surgery or corticosteroids
- Pregnant or breastfeeding females
- Sexually active patients not using effective contraception during study
- Failure to provide informed consent or meet institutional and regulatory requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 109 locations
1
USA Health Strada Patient Care Center
Mobile, Alabama, United States, 36604
Actively Recruiting
2
Phoenix Childrens Hospital
Phoenix, Arizona, United States, 85016
Actively Recruiting
3
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202-3591
Actively Recruiting
4
Loma Linda University Medical Center
Loma Linda, California, United States, 92354
Actively Recruiting
5
Children's Hospital Los Angeles
Los Angeles, California, United States, 90027
Actively Recruiting
6
UCSF Benioff Children's Hospital Oakland
Oakland, California, United States, 94609
Actively Recruiting
7
Children's Hospital of Orange County
Orange, California, United States, 92868
Actively Recruiting
8
Lucile Packard Children's Hospital Stanford University
Palo Alto, California, United States, 94304
Actively Recruiting
9
Rady Children's Hospital - San Diego
San Diego, California, United States, 92123
Actively Recruiting
10
UCSF Medical Center-Mission Bay
San Francisco, California, United States, 94158
Actively Recruiting
11
Children's Hospital Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
12
Connecticut Children's Medical Center
Hartford, Connecticut, United States, 06106
Actively Recruiting
13
Alfred I duPont Hospital for Children
Wilmington, Delaware, United States, 19803
Actively Recruiting
14
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
15
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida, United States, 33021
Actively Recruiting
16
Nemours Children's Clinic-Jacksonville
Jacksonville, Florida, United States, 32207
Actively Recruiting
17
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States, 33136
Actively Recruiting
18
Nicklaus Children's Hospital
Miami, Florida, United States, 33155
Actively Recruiting
19
Arnold Palmer Hospital for Children
Orlando, Florida, United States, 32806
Actively Recruiting
20
Nemours Children's Hospital
Orlando, Florida, United States, 32827
Actively Recruiting
21
Nemours Children's Clinic - Pensacola
Pensacola, Florida, United States, 32504
Actively Recruiting
22
Sacred Heart Hospital
Pensacola, Florida, United States, 32504
Active, Not Recruiting
23
Johns Hopkins All Children's Hospital
St. Petersburg, Florida, United States, 33701
Actively Recruiting
24
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida, United States, 33607
Actively Recruiting
25
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, United States, 30329
Actively Recruiting
26
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, United States, 96826
Actively Recruiting
27
Saint Luke's Cancer Institute - Boise
Boise, Idaho, United States, 83712
Actively Recruiting
28
Lurie Children's Hospital-Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
29
University of Illinois
Chicago, Illinois, United States, 60612
Actively Recruiting
30
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States, 60637
Actively Recruiting
31
Loyola University Medical Center
Maywood, Illinois, United States, 60153
Actively Recruiting
32
Riley Hospital for Children
Indianapolis, Indiana, United States, 46202
Actively Recruiting
33
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, United States, 52242
Actively Recruiting
34
Norton Children's Hospital
Louisville, Kentucky, United States, 40202
Actively Recruiting
35
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, United States, 21287
Actively Recruiting
36
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
37
C S Mott Children's Hospital
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
38
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
39
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis, Minnesota, United States, 55404
Actively Recruiting
40
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
41
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
42
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Actively Recruiting
43
Children's Mercy Hospitals and Clinics
Kansas City, Missouri, United States, 64108
Actively Recruiting
44
Cardinal Glennon Children's Medical Center
St Louis, Missouri, United States, 63104
Actively Recruiting
45
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
46
Children's Hospital and Medical Center of Omaha
Omaha, Nebraska, United States, 68114
Actively Recruiting
47
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
48
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, United States, 89135
Actively Recruiting
49
Summerlin Hospital Medical Center
Las Vegas, Nevada, United States, 89144
Actively Recruiting
50
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
51
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
52
Saint Peter's University Hospital
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
53
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, New Jersey, United States, 08903
Actively Recruiting
54
Newark Beth Israel Medical Center
Newark, New Jersey, United States, 07112
Actively Recruiting
55
Saint Joseph's Regional Medical Center
Paterson, New Jersey, United States, 07503
Actively Recruiting
56
Albany Medical Center
Albany, New York, United States, 12208
Actively Recruiting
57
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park, New York, United States, 11040
Actively Recruiting
58
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, United States, 10016
Actively Recruiting
59
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
60
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, United States, 10032
Actively Recruiting
61
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
62
State University of New York Upstate Medical University
Syracuse, New York, United States, 13210
Actively Recruiting
63
Montefiore Medical Center - Moses Campus
The Bronx, New York, United States, 10467
Actively Recruiting
64
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
65
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
66
Sanford Broadway Medical Center
Fargo, North Dakota, United States, 58122
Actively Recruiting
67
Rainbow Babies and Childrens Hospital
Cleveland, Ohio, United States, 44106
Actively Recruiting
68
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
69
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
70
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
71
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
72
Saint Christopher's Hospital for Children
Philadelphia, Pennsylvania, United States, 19134
Actively Recruiting
73
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
74
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
Actively Recruiting
75
Prisma Health Richland Hospital
Columbia, South Carolina, United States, 29203
Actively Recruiting
76
BI-LO Charities Children's Cancer Center
Greenville, South Carolina, United States, 29605
Actively Recruiting
77
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, United States, 57117-5134
Actively Recruiting
78
Saint Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105
Actively Recruiting
79
Dell Children's Medical Center of Central Texas
Austin, Texas, United States, 78723
Actively Recruiting
80
Driscoll Children's Hospital
Corpus Christi, Texas, United States, 78411
Actively Recruiting
81
Medical City Dallas Hospital
Dallas, Texas, United States, 75230
Actively Recruiting
82
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, United States, 75390
Actively Recruiting
83
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
84
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
85
Children's Hospital of San Antonio
San Antonio, Texas, United States, 78207
Actively Recruiting
86
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
87
Primary Children's Hospital
Salt Lake City, Utah, United States, 84113
Actively Recruiting
88
University of Virginia Cancer Center
Charlottesville, Virginia, United States, 22908
Actively Recruiting
89
Children's Hospital of The King's Daughters
Norfolk, Virginia, United States, 23507
Actively Recruiting
90
Seattle Children's Hospital
Seattle, Washington, United States, 98105
Actively Recruiting
91
Providence Sacred Heart Medical Center and Children's Hospital
Spokane, Washington, United States, 99204
Actively Recruiting
92
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, United States, 53792
Actively Recruiting
93
John Hunter Children's Hospital
Hunter Regional Mail Centre, New South Wales, Australia, 2310
Actively Recruiting
94
Sydney Children's Hospital
Randwick, New South Wales, Australia, 2031
Actively Recruiting
95
The Children's Hospital at Westmead
Westmead, New South Wales, Australia, 2145
Actively Recruiting
96
Queensland Children's Hospital
South Brisbane, Queensland, Australia, 4101
Actively Recruiting
97
Royal Children's Hospital
Parkville, Victoria, Australia, 3052
Actively Recruiting
98
Perth Children's Hospital
Perth, Western Australia, Australia, 6009
Actively Recruiting
99
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
100
British Columbia Children's Hospital
Vancouver, British Columbia, Canada, V6H 3V4
Actively Recruiting
101
CancerCare Manitoba
Winnipeg, Manitoba, Canada, R3E 0V9
Actively Recruiting
102
IWK Health Centre
Halifax, Nova Scotia, Canada, B3K 6R8
Actively Recruiting
103
McMaster Children's Hospital at Hamilton Health Sciences
Hamilton, Ontario, Canada, L8N 3Z5
Actively Recruiting
104
Children's Hospital
London, Ontario, Canada, N6A 5W9
Actively Recruiting
105
Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8
Actively Recruiting
106
The Montreal Children's Hospital of the MUHC
Montreal, Quebec, Canada, H3H 1P3
Actively Recruiting
107
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada, H3T 1C5
Actively Recruiting
108
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada, J1H 5N4
Actively Recruiting
109
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
Québec, Canada, G1V 4G2
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
7
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