Transcranial Direct Current Stimulation Combined With Treadmill Training With Partial Body Weight Support in Patients With Multiple Sclerosis

What this Trial Is About

Researchers are evaluating the therapeutic effects of transcranial direct current stimulation (tDCS), a non-invasive method that alters brain activity, combined with gait training in people with multiple sclerosis (MS). The study aims to improve balance and walking ability, which are often affected in MS patients, using a randomized, triple-blind, controlled design comparing active tDCS with sham stimulation alongside identical gait training. This builds on previous evidence suggesting beneficial effects of tDCS in MS and seeks to confirm these findings with an optimized stimulation approach. Participants will receive either active tDCS or sham stimulation using the same device and electrode placement. Active tDCS applies 2 mA current for 20 minutes with electrodes placed on the head and right shoulder, secured with a cap and bandage. The sham group receives a brief, low-level stimulation mimicking the device's sensations without therapeutic current. Both groups will undergo 20-minute treadmill gait training sessions supported by a body-weight support harness to promote motor relearning and ensure safety. During the study, participants will be assessed before treatment, after the 10th session, and at a 4-week follow-up. Researchers will measure walking speed and balance using tests like the Timed Up and Go (TUG) and Timed 25-Foot Walk, along with questionnaires on walking ability and fatigue. Safety and clinical outcomes will be monitored throughout, with the total participation duration spanning the intervention and follow-up periods.

tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis