Actively Recruiting
tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis
Led by University of Castilla-La Mancha · Updated on 2025-05-29
78
Participants Needed
2
Research Sites
31 weeks
Total Duration
On this page
Sponsors
U
University of Castilla-La Mancha
Lead Sponsor
A
Asociación Esclerosis Múltiple de Toledo, España
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.
CONDITIONS
Official Title
tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to understand and follow instructions
- Diagnosis of Multiple Sclerosis according to McDonald criteria
- Expanded Disability Status Scale (EDSS) between 1 and 6
- Stable condition in the last three months
You will not qualify if you...
- Peripheral neurological injury of lower limbs
- Metal objects in the head
- Uncontrolled epilepsy
- Diagnosis of psychiatric disorder
- Fractures or fissures in the skull
- Presence of any implanted electronic device (pacemaker, baclofen pump)
- Presence of ulcers in the harness attachment area
- Osteoporotic fractures in the last 2 years
- Height > 190 cm
- Weight > 120 kg
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Asociación de Esclerosis Múltiple de Toledo
Toledo, Toledo, Spain, 45071
Actively Recruiting
2
Universidad de Castilla La Mancha
Toledo, Toledo, Spain, 45071
Enrolling by Invitation
Research Team
D
Diego Serrano Muñoz, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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