Non-Invasive Brain Stimulation Combined With Treadmill Training to Improve Walking in Adults With Multiple Sclerosis

What this Trial Is About

Researchers are evaluating the therapeutic effects of transcranial direct current stimulation tDCS, a non-invasive method that alters brain activity, combined with gait training in people with multiple sclerosis MS. The study aims to improve balance and walking ability, which are often affected in MS patients, using a randomized, triple-blind, controlled design comparing active tDCS with sham stimulation alongside identical gait training. This builds on previous evidence suggesting beneficial effects of tDCS in MS and seeks to confirm these findings with an optimized stimulation approach. Participants will receive either active tDCS or sham stimulation using the same device and electrode placement. Active tDCS applies 2 mA current for 20 minutes with electrodes placed on the head and right shoulder, secured with a cap and bandage. The sham group receives a brief, low-level stimulation mimicking the devices sensations without therapeutic current. Both groups will undergo 20-minute treadmill gait training sessions supported by a body-weight support harness to promote motor relearning and ensure safety. During the study, participants will be assessed before treatment, after the 10th session, and at a 4-week follow-up. Researchers will measure walking speed and balance using tests like the Timed Up and Go TUG and Timed 25-Foot Walk, along with questionnaires on walking ability and fatigue. Safety and clinical outcomes will be monitored throughout, with the total participation duration spanning the intervention and follow-up periods.

tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis