Actively Recruiting
The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments
Led by University of California, Irvine · Updated on 2026-03-18
210
Participants Needed
1
Research Sites
176 weeks
Total Duration
On this page
Sponsors
U
University of California, Irvine
Lead Sponsor
U
University of California, Los Angeles
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this 2-arm randomized control trial is to determine the impact of a community health worker delivered coaching intervention, GRIT, on preventing the early initiation of regular use of alcohol and cannabis among adversity-impacted adolescents ages 11-14 who do not regularly use alcohol or cannabis at baseline. The specific aims include: * Aim 1. Examine the effect of GRIT on preventing the early initiation of regular alcohol and cannabis use over time. * Aim 2. Examine the role of youth and caregiver self-regulation in mediating the effect of GRIT on adolescent rates of alcohol and cannabis use. Researchers will compare participants who are randomized to the GRIT intervention to an active control group, receiving a Digital Citizenship Curriculum, to see if those who participate in GRIT experience greater improvements in self-regulation and lower cardiometabolic risks. Participants will: * Be randomized to either receive the GRIT intervention (experimental group) or the Digital Citizenship Curriculum (active control group) * Complete 3 in-person visits at baseline, post-intervention, and 12-month post intervention * Complete HRV assessments using emWave Pro Plus and survey assessments on REDCap during in-person visits. * Participate in six 60-minute sessions conducted over 8 weeks via Zoom with an assigned community-health worker * Be invited to complete a booster session at 6-months post-intervention * Complete online measures at baseline, post-intervention, 6-month, and 12-month post-intervention
CONDITIONS
Official Title
The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Youth ages 11 to 14 years who have four or more adverse childhood experiences (ACEs)
- Has access to a smartphone and is willing to download apps
- Youth can speak and read English
- Has a parent or primary caregiver aged 18 or older who speaks English or Spanish and is willing to participate
You will not qualify if you...
- Youth who cannot speak and read English
- Youth who have used alcohol or cannabis in the past 14 days
- Youth enrolled in another family-based intervention such as family therapy
- Youth in acute distress needing immediate care (e.g., risk of harm, active psychosis)
- Youth whose home environment is unsafe or requires supervised visits by child services
- Youth whose caregiver declines participation
- Youth who report recent cannabis use but do not use within the last two weeks and have a negative urine drug test
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Regents of the University of California, Irvine
Irvine, California, United States, 92697-7600
Actively Recruiting
Research Team
D
Dawn T. Bounds, Ph.D.
CONTACT
J
Jenny Fotang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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