Actively Recruiting
Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
Led by University of Florida · Updated on 2025-05-08
120
Participants Needed
2
Research Sites
158 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.
CONDITIONS
Official Title
Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 or older
- Mild to moderate decline in executive function based on standardized tests
- Experience of worsening confusion or memory loss in the past 12 months
- Ability to walk independently for 6 minutes, with or without a cane
You will not qualify if you...
- Major cognitive disorder that affects independence
- Scoring below the 10th percentile on cognitive assessments
- Taking medications that may influence brain stimulation effects
- Contraindications to transcranial direct current stimulation or MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
University of Florida
Gainesville, Florida, United States, 32610
Actively Recruiting
2
Brooks Rehabilitation
Jacksonville, Florida, United States, 32653
Actively Recruiting
Research Team
D
David J Clark, ScD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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