Actively Recruiting
Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
Led by Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Updated on 2026-04-27
140
Participants Needed
1
Research Sites
175 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). The main questions it aims to answer are: * Is the type 2 inflammation impacting the olfactory epithelium regeneration, leading to OD? * Does a treatment interfering with one of the major T2 inflammatory cytokines, have an impact on the mechanisms of OD in CRS? Participants will undergo olfactory testing and nasal brushing before and after 3 months of treatment.
CONDITIONS
Official Title
Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least two of the following symptoms for 12 weeks: nasal obstruction, rhinorrhoea, smell loss, facial pain
- Endoscopic visualization of bilateral sinonasal polyps
- Smell test score (SSI TDI) less than 30.75 and subjective decrease in sense of smell
- Blood eosinophil count greater than 300/bcl
- Stable nasal steroid treatment for at least 4 weeks prior to study
You will not qualify if you...
- Active smoking
- Primary or secondary immune deficiencies
- Ciliary diseases such as cystic fibrosis or primary ciliary dyskinesia
- History or current nasal cancers
- Younger than 18 years or older than 70 years
- Unable to provide informed consent
- Use of systemic corticosteroids less than 4 weeks before first visit
- Use of systemic or local antibiotics less than 4 weeks before first visit
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cliniques Universitaires Saint-Luc
Brussels, Belgium, 1200
Actively Recruiting
Research Team
V
Valérie Hox, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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