Study of Upper Airway Inflammation and Its Effect on Smell Loss and Recovery in Chronic Rhinosinusitis With Nasal Polyps

What this Trial Is About

Researchers are investigating how olfactory dysfunction OD develops in people with chronic rhinosinusitis with nasal polyps CRSwNP. They want to understand if type 2 inflammation affects the regeneration of the olfactory epithelium, which may lead to loss of smell. The study also evaluates whether treatments targeting a major type 2 inflammatory cytokine can influence the mechanisms behind this smell loss. Participants with chronic rhinosinusitis will undergo smell testing using the Sniffin Sticks Test and nasal brushing of the olfactory cleft before and after 3 months of treatment. These procedures help researchers study the olfactory epithelium and its function. The study includes one group of patients who receive this evaluation. During the study, participants will have genetic profiling through single-cell RNA sequencing and functional assessments of the olfactory epithelium over about 2 years. Researchers will track changes before and after treatment to understand recovery mechanisms. The total participation involves initial testing, treatment monitoring, and follow-up evaluations to assess olfactory function and tissue characteristics.

Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery