Actively Recruiting

Age: 37Years - 94Years
All Genders
Healthy Volunteers
ID05893524

Uppsala-Dalarna Dementia and Gait Project Using Timed Up-and-Go Dual-Task Test for Early Identification and Prediction of Dementia

Led by Dalarna University · Updated on 2025-02-12

550

Participants Needed

2

Research Sites

N/A

Total Duration

On this page

Sponsors

D

Dalarna University

Lead Sponsor

U

Uppsala University

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are studying a new way to identify early signs of cognitive problems and risk of dementia by combining a walking test called Timed Up-and-Go (TUG) with a verbal task, known as the TUG dual-task (TUGdt). This study aims to find out if this combined test can help predict dementia, evaluate how well the test works, and create reference values from healthy individuals to compare results. The project is a multidisciplinary observational research effort led by Dalarna University. Participants include people undergoing memory assessments at two specialist clinics, as well as healthy volunteers matched by age. They perform tests including the TUG single-task and two types of TUG dual-task tests where they name animals or recite months backwards while moving. Other assessments include cognitive tests like the Mini-Mental State Examination and motor function tests such as balance and hand grip strength. Some participants are retested to check the reliability of the tests. During the study, participants are observed over up to 10 years to see if they develop dementia and to track their cognitive function levels. Researchers collect data from clinical evaluations, cognitive and motor tests, and the TUG tests to understand how these measurements relate to dementia risk. The study involves regular assessments and uses the clinical routine evaluations from memory clinics, without involving experimental treatments.

CONDITIONS

Brief Title

Uppsala-Dalarna Dementia and Gait Project

Who Can Participate

Age: 37Years - 94Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients undergoing memory assessment at Uppsala University Hospital, Sweden
  • Patients undergoing memory assessment at Falu Hospital, Sweden
  • Cognitively unimpaired individuals with a Mini Mental State Examination (MMSE) score greater than 26
Not Eligible

You will not qualify if you...

  • Inability to walk three meters back and forth
  • Inability to rise from a sitting position
  • Indoor use of a walking aid
  • Current or recent hospitalization within the last 2 weeks
  • Need of an interpreter to communicate in Swedish

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Up to 10 years

Participants undergo clinical functional assessments and Timed Up-and-Go tests to evaluate cognitive and motor function as part of routine memory assessment.

Initial assessment with possible retesting visits depending on cohort assignment

Long-term Monitoring

Duration - Up to 10 years

Participants are monitored over time to observe conversion to dementia and changes in cognitive functioning.

Periodic follow-up visits over several years

Trial Site Locations

Total: 2 locations

1

Dalarna University

Falun, Dalarna County, Sweden, 79188

Completed

2

Uppsala University

Uppsala, Uppsala County, Sweden, 751 22

Actively Recruiting

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Research Team

A

Anna Cristina Åberg, PhD

V

Vilmantas Giedraitis, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

4

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Published Research Related To This Trial

Dual-Task Performance and Neurodegeneration: Correlations Between Timed Up-and-Go Dual-Task Test Outcomes and Alzheimer's Disease Cerebrospinal Fluid Biomarkers.

Hanna Bozkurt Åhman, Vilmantas Giedraitis, Ylva Cedervall...

https://pubmed.ncbi.nlm.nih.gov/31104024

Timed Up-and-Go Dual-Task Testing in the Assessment of Cognitive Function: A Mixed Methods Observational Study for Development of the UDDGait Protocol.

Ylva Cedervall, Anna M Stenberg, Hanna B Åhman...

https://pubmed.ncbi.nlm.nih.gov/32150995

Dual-task tests discriminate between dementia, mild cognitive impairment, subjective cognitive impairment, and healthy controls - a cross-sectional cohort study.

Hanna B Åhman, Ylva Cedervall, Lena Kilander...

https://pubmed.ncbi.nlm.nih.gov/32727472

The Timed Up and Go dual-task test's cognitive and motor outcomes show promising test-retest reliability in older adults with perceived memory impairment.

Niklas Löfgren, Vilmantas Giedraitis, Kjartan Halvorsen...

https://pubmed.ncbi.nlm.nih.gov/41585362

Can Turn Duration and Step Parameters During the Timed Up and Go Test With and Without a Dual-Task Discriminate Between Individuals With Different Cognitive Abilities? An Explorative Study.

Niklas Löfgren, Lars Berglund, Vilmantas Giedraitis...

https://pubmed.ncbi.nlm.nih.gov/41572419

Extracted step parameters during the timed up and go test discriminate between groups with different levels of cognitive ability-a cross-sectional study.

Niklas Löfgren, Lars Berglund, Vilmantas Giedraitis...

https://pubmed.ncbi.nlm.nih.gov/40097949

Prediction of conversion to dementia disorders based on timed up and go dual-task test verbal and motor outcomes: a five-year prospective memory-clinic-based study.

Anna Cristina Åberg, Johanna R Petersson, Vilmantas Giedraitis...

https://pubmed.ncbi.nlm.nih.gov/37660032