Actively Recruiting
Validating Gulf War Illness Blood Biomarkers
Led by Roskamp Institute Inc. · Updated on 2025-07-24
100
Participants Needed
3
Research Sites
191 weeks
Total Duration
On this page
Sponsors
R
Roskamp Institute Inc.
Lead Sponsor
B
Boston University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators goals are to identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI. To determine the effect of dietary, medical and biological factors that influence lipid and metabolites in blood from GW veterans. To identify blood lipid/metabolite profiles that correlate with bioenergetics deficits and glial activation in the brains of GWI. To validate blood biomarker signatures of GWI using APOE genotyping and blood lipids/metabolites that correlate with the CNS dysfunction in GWI.
CONDITIONS
Official Title
Validating Gulf War Illness Blood Biomarkers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 35 years or older
- For GWI cases, served in the 1990-1991 Gulf War as active duty, national guard, or reserves and meet criteria for the CDC Chronic Multisymptom Illness (CMI) GWI definition or Kansas GWI definition
- For controls, must be a veteran in the same age range as those veterans with GWI
- Ability to understand written and spoken English or have a legal representative who can
- Participants and caregivers must be able to read, write, and speak the language of psychometric tests with sufficient corrected visual and auditory acuity for accurate testing
You will not qualify if you...
- Diagnosed or treated for cancer (except non-melanoma skin cancers)
- Diagnosed or treated for chronic infectious disease
- Problems from postwar injuries
- Liver disease
- Lupus
- Multiple sclerosis
- Stroke
- Serious psychiatric conditions associated with psychosis or hospitalization since 1991
- Dementia or any type of Parkinson's disease
- Hospitalized in the last 5 years for alcohol or drug dependence, depression, or PTSD
- Female participants who are pregnant or nursing
AI-Screening
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Trial Site Locations
Total: 3 locations
1
Palto Alto Veterans Institute for Research
Palo Alto, California, United States, 94304
Actively Recruiting
2
The Roskamp Institute
Sarasota, Florida, United States, 34232
Actively Recruiting
3
Boston University
Boston, Massachusetts, United States, 02118
Actively Recruiting
Research Team
D
Dakota Helgager, B.S
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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