Actively Recruiting
Coenzyme Q10 for Gulf War Illness: A Replication Study
Led by University of California, San Diego · Updated on 2026-05-01
192
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of California, San Diego
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating whether a high-quality preparation of ubiquinone (coenzyme Q10) can improve symptoms, function, and quality of life in veterans with Gulf War illness. This Phase 3 study focuses on veterans who meet specific deployment and symptom criteria and aims to replicate previous findings related to coenzyme Q10’s potential effects in this population. Participants are randomly assigned to one of three groups: one group receives 100 mg of PharmaNord Bio-Quinone Active CoQ10 Gold once daily with placebo softgels to match dosing; a second group receives 100 mg three times daily; and the third group receives placebo softgels three times daily. The supplement is taken orally in divided doses, with the last dose not close to bedtime. Treatment lasts for 3.5 months. During the study, participants will complete symptom surveys, timed chair rise tests, and general self-rated health assessments. Blood samples will be collected to measure coenzyme Q10 levels. Researchers will monitor changes in symptoms and physical function at 3.5 and 7 months. The study includes remote visits via Zoom and requires participants to have adequate internet access. The total participation duration includes treatment and follow-up assessments, with safety and adherence monitored throughout.
CONDITIONS
Brief Title
Coenzyme Q10 for Gulf War Illness: A Replication Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meets both CDC and Kansas deployment and symptom inclusion criteria
- Does not have a disqualifying condition
- Able to travel to a local Quest facility for study blood draws
- Has adequate internet access to allow ZoomPro visit participation and remote survey completion
- Health prior to the Gulf War rated as "very good" or "excellent"
- Willing to delay starting any additional treatments or supplements during the study
You will not qualify if you...
- Participating in another clinical trial
- Experiencing ongoing adverse effects from another medication or health condition, such as COVID-19 or fluoroquinolone use
- Taking Coumadin/warfarin
- Unable to participate for the full required duration of the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3.5 months
Participants take Coenzyme Q10 or placebo three times a day as assigned to assess effects on Gulf War Illness symptoms.
Weekly visits for up to 3.5 months
Duration - Up to 3.5 additional months
Participants are monitored for continued effects and symptom changes after treatment ends.
Monthly visits up to 7 months from start
Trial Site Locations
Total: 1 location
1
UC San Diego
La Jolla, California, United States, 92093
Actively Recruiting
Research Team
J
Janis B Ritchie, BSN
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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