Actively Recruiting

Phase Not Applicable
Age: 20Years - 65Years
FEMALE
ID06735651

Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Female Adults With Prediabetes

Led by Georgia State University · Updated on 2026-03-25

30

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

G

Georgia State University

Lead Sponsor

W

Wild Blueberry Association of North America

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are studying the effects of freeze-dried wild blueberry powder on heart, brain, and gut health in adult women with prediabetes. The study aims to understand how daily blueberry intake might improve blood sugar control, blood pressure, cognitive functions like memory and thinking skills, and gut bacteria balance in this group. This research addresses the high risk of cardiovascular disease and dementia in people with type 2 diabetes and prediabetes, focusing on lifestyle changes that include dietary improvements. This six-week, randomized, placebo-controlled trial compares two groups of women with prediabetes. One group consumes 22 grams of freeze-dried wild blueberry powder daily, while the other takes a similar macronutrient-matched placebo powder. The study is triple-blinded, meaning neither participants nor researchers know who receives which powder during the trial. Participants will undergo assessments at the start and end of the study to measure blood glucose, blood pressure, insulin levels, insulin resistance, lipid profile, gut microbiota composition, and cognitive abilities such as memory, attention, and problem-solving. Researchers will also monitor markers of oxidative stress and inflammation. The overall participation lasts six weeks, with evaluations designed to understand the relationships between gut health, heart health, and cognitive function in women with prediabetes.

CONDITIONS

Brief Title

Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes

Who Can Participate

Age: 20Years - 65Years
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • Women aged 20 to 65 years old
  • Diagnosed with prediabetes (fasting blood glucose 100-125 mg/dL and/or HbA1c 5.7%-6.4%)
  • Body mass index between 25 and 30 kg/m²
Not Eligible

You will not qualify if you...

  • Allergy to berries
  • Use of insulin, antidiabetic, antibiotics, or anti-inflammatory medications
  • Active cancer, gastrointestinal, kidney, thyroid, neurological diseases, severe head injury, or cardiovascular diseases including stage 1 and 2 hypertension
  • Smoking
  • Consuming more than 2 alcoholic drinks per day
  • Use of antioxidant, probiotic, or prebiotic supplements
  • Pregnant or breastfeeding
  • Currently in a weight loss program
  • Taking berry supplements or recently participated in a berry supplement study

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 6 weeks

Participants consume daily 22 g of freeze-dried wild blueberry powder or placebo for 6 weeks to study effects on gut, cardiometabolic, and cognitive health.

Baseline visit and 1 follow-up visit

Trial Site Locations

Total: 1 location

1

Georgia State University

Atlanta, Georgia, United States, 30303

Actively Recruiting

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Research Team

R

Rafaela G Feresin, PhD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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Published Research Related To This Trial

Effect of Blueberry Consumption on Cardiometabolic Health Parameters in Men with Type 2 Diabetes: An 8-Week, Double-Blind, Randomized, Placebo-Controlled Trial.

Kim S Stote, Margaret M Wilson, Deborah Hallenbeck...

https://pubmed.ncbi.nlm.nih.gov/32337475

Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial.

Marshall G Miller, Derek A Hamilton, James A Joseph...

https://pubmed.ncbi.nlm.nih.gov/28283823

Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial.

Sarah A Johnson, Arturo Figueroa, Negin Navaei...

https://pubmed.ncbi.nlm.nih.gov/25578927