Identifying Key 3D Dynamic and Mechanical Factors to Improve Treatment Decisions in Adolescent Idiopathic Scoliosis

What this Trial Is About

Adolescent Idiopathic Scoliosis AIS is a spinal growth defect mostly affecting prepubertal children aged 10 to 14 years, causing lateral curves and rotations of the spine. AIS can lead to posture problems, back pain, and visible asymmetry, such as uneven shoulders. Early diagnosis and proper treatment are important to stop curve progression and reduce related health issues. Current surgical decisions rely on two-dimensional X-rays, which may not capture the full three-dimensional and dynamic nature of the spines deformity, leading to suboptimal outcomes and revision surgeries. Treatment options include wearing a brace for immature patients with curves between 25 and 40 degrees. If the curve does not respond and growth potential remains, vertebral body tethering VBT, a minimally invasive FDA-approved device that gradually corrects scoliosis by slowing growth on one side, may be considered. For curves of 50 degrees or more with little growth left, spinal fusion surgery is recommended to permanently correct the spine by attaching vertebrae with surgical hardware. The study aims to improve surgical planning by using 3D dynamic and mechanical information from musculoskeletal models, moving beyond current 2D static assessments. Participants will undergo questionnaires, radiological EOS scans, and 3D dynamic motion analyses to gather detailed data on spinal deformity and mechanics. Researchers will measure 3D dynamic parameters up to two years after surgery and develop biomechanically-informed 3D models specific to AIS. This approach hopes to help surgeons make evidence-based decisions, improve patient outcomes, reduce complications, and lower the costs associated with AIS treatment. The study is sponsored by Universitaire Ziekenhuizen KU Leuven and involves patients aged 10 to 35 undergoing VBT or selective fusion surgery.

3D, Dynamic and Mechanically-informed Decision Making in AIS