Actively Recruiting
Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis
Led by University of Colorado, Denver · Updated on 2023-09-28
380
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying adolescent idiopathic scoliosis (AIS), a common spine condition in children whose causes and progression are not well understood. This study aims to identify genetic markers linked to the worsening of spinal curves in girls aged 10 to 13 with mild to moderate scoliosis. Understanding these markers could help predict which patients may need early surgery and improve screening for children at risk. The study does not involve treatment but focuses on observing and analyzing specific cell signaling factors over time. Participants will be monitored to see how their spinal curves progress, especially tracking changes over three years. This observational approach seeks to gather data that could lead to less invasive and more reliable tests for scoliosis progression in the future. Participants will be followed for up to three years, during which researchers will assess spine curve changes using clinical measurements. The main outcome measured is scoliosis curve progression over this period. This long-term follow-up will help scientists understand how genetic markers relate to disease progression and inform future diagnostic methods. The study is sponsored by the University of Colorado, Denver.
CONDITIONS
Brief Title
Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female aged 10 to 13 years
- Diagnosed with mild to moderate spine deformity with a Cobb angle between 15 and 30 degrees
You will not qualify if you...
- Scoliosis caused by conditions other than idiopathic scoliosis
- History of trauma
- Presence of inflammatory disease
- Diagnosis of malignancies
- Diagnosis of diabetes
- Previous spine surgery history
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 years
Participants are monitored over time to observe scoliosis curve progression.
Periodic visits for assessments over 3 years
Trial Site Locations
Total: 1 location
1
Children'S Hospital of Colorado
Denver, Colorado, United States, 80045
Actively Recruiting
Research Team
J
jiandong hao
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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