Study of Cell Signaling Markers to Predict Curve Progression in Adolescent Female Idiopathic Scoliosis Ages 10 to 13

What this Trial Is About

Researchers are studying adolescent idiopathic scoliosis AIS, a common spine condition in children whose causes and progression are not well understood. This study aims to identify genetic markers linked to the worsening of spinal curves in girls aged 10 to 13 with mild to moderate scoliosis. Understanding these markers could help predict which patients may need early surgery and improve screening for children at risk. The study does not involve treatment but focuses on observing and analyzing specific cell signaling factors over time. Participants will be monitored to see how their spinal curves progress, especially tracking changes over three years. This observational approach seeks to gather data that could lead to less invasive and more reliable tests for scoliosis progression in the future. Participants will be followed for up to three years, during which researchers will assess spine curve changes using clinical measurements. The main outcome measured is scoliosis curve progression over this period. This long-term follow-up will help scientists understand how genetic markers relate to disease progression and inform future diagnostic methods. The study is sponsored by the University of Colorado, Denver.

Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis