Actively Recruiting
Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis
Led by University of Colorado, Denver · Updated on 2023-09-28
380
Participants Needed
1
Research Sites
630 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to identify potential markers for curve progression in adolescent idiopathic scoliosis (AIS). Despite its prevalence and impact on child health, the etiology of AIS and molecular mechanisms underlying its development and progression remain poorly understood. Clinical criteria and features cannot adequately predict which children, diagnosed with mild disease, will undergo subsequent curve progression requiring intervention. The investigators hypothesize that alterations in specific genetic markers will be correlated with the progression of AIS curves over time. Thus, these markers could be used in the future to develop a reliable, inexpensive and relatively non-invasive cell based diagnostic test to (1) predict spinal curve progression in AIS, (2) select patients likely to benefit from early surgical intervention, and (3) potentially screen for asymptomatic children at risk of developing idiopathic scoliosis.
CONDITIONS
Official Title
Analysis of Prognostic Cell Signaling Factors in Adolescent Idiopathic Scoliosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female participants aged 10 to 13 years
- Diagnosed with mild to moderate spine deformity (Cobb angle 15-30 degrees)
You will not qualify if you...
- Scoliosis caused by conditions other than idiopathic
- History of trauma
- Presence of inflammatory disease
- Presence of malignancies
- Diagnosis of diabetes
- Previous spine surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children'S Hospital of Colorado
Denver, Colorado, United States, 80045
Actively Recruiting
Research Team
J
jiandong hao
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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