Inclusion Criteria:

• Meets criteria for alcohol dependence.
• Expresses a desire to cut down or stop drinking.

Exclusion Criteria:

• Currently meets criteria for dependence on substances other than alcohol.
• History of opiate dependence or evidence of current opiate use.
• Significant medical disorders that will increase potential risk or interfere with study participation.
• Liver function tests more than 3 times normal or elevated bilirubin.
• Female patients who are pregnant, nursing, or not using a reliable method of birth control.
• Inability to understand and provide a consent form.
• Treatment with an investigational drug during the previous month.
• Prior treatment with naltrexone.
• Chronic treatment with any narcotic-containing medications during the previous month.
• Sensitivity to naltrexone as evidenced by adverse drug experiences especially with narcotic containing analgesics or opioid antagonists.
• Current treatment with disulfiram.
• More than 6 weeks of abstinence.
• Meets criteria for a major psychiatric disorder and is in need of, or currently undergoing pharmacotherapy.