Successful smoking cessation is associated with prefrontal cortical function during a Stroop task: A preliminary study.
Klaus-Martin Krönke, Max Wolff, Annika Benz...
https://pubmed.ncbi.nlm.nih.gov/26321462/Actively Recruiting
Led by Technische Universität Dresden · Updated on 2024-11-22
180
Participants Needed
1
Research Sites
117 weeks
Total Duration
Researchers are investigating how habitual behaviors and goal-directed control interact and differ in people with Alcohol Use Disorder AUD compared to those without substance use disorders. The study aims to understand whether stronger habits and conflicts between habitual and goal-directed actions relate to AUD, and to explore whether Pavlovian-to-Instrumental Transfer PIT reflects automatic or controlled behavior. Additionally, the study seeks to confirm if severely dependent AUD patients show a stronger PIT effect than controls. Participants will complete behavioral tasks over two days. They will perform the Action Sequence Task AST, which involves pressing keys in sequences linked to rewards, measuring automation and conflict between habitual and goal-directed responses. On the second day, they will also do the single-lever PIT task, involving learning to collect shells for money and responding to cues associated with gains or losses. Additional tasks include the Counting Stroop task and the No-go Simon task to assess interference and response inhibition. During the study, participants will undergo assessments including interviews and questionnaires about substance use and psychological traits. Researchers will measure task performance, error rates, and reaction times to evaluate habitual behavior and interference effects. The primary outcomes focus on results from the PIT and AST tasks, with secondary outcomes from the Stroop and Simon tasks. The study lasts for two days of testing, with a total participation time of a few hours.
CONDITIONS
Assessing Habitual, Goal-Directed, and Pavlovian Influences in Alcohol Use Disorder
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Technische Universität Dresden
Lead Sponsor
Charite University, Berlin, Germany
Collaborating Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 2 days
Participants complete behavioral tasks including the Action Sequence Task (AST) over two consecutive days, the single-lever Pavlovian-to-instrumental transfer (PIT) task, and neuropsychology tests such as the Counting Stroop Task and Go/No-Go Simon task. Additionally, participants undergo structured clinical interviews and complete questionnaires assessing various psychological and substance use parameters.
2 visits (in-person) over 2 consecutive days
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Have more questions? Get in touch with our team for quick support
Klaus-Martin Krönke, Max Wolff, Annika Benz...
https://pubmed.ncbi.nlm.nih.gov/26321462/Matthew J Belanger, Hao Chen, Angela Hentschel...
https://pubmed.ncbi.nlm.nih.gov/36380640/Sascha Frölich, Marlon Esmeyer, Tanja Endrass...
https://pubmed.ncbi.nlm.nih.gov/36711151/Witold X Chmielewski, Christian Beste
https://pubmed.ncbi.nlm.nih.gov/27742599/Technische Universität Dresden
Lead Sponsor
Charite University, Berlin, Germany
Collaborating Sponsor