Actively Recruiting
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
Led by Yale University · Updated on 2025-09-11
80
Participants Needed
1
Research Sites
253 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.
CONDITIONS
Official Title
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 21-60 years
- Physically healthy based on medical history, physical exam, neurological exam, ECG, and lab tests
- For females, a negative serum pregnancy test
- For cocaine use disorder group: DSM-5 diagnosis of cocaine use disorder and positive urine test for recent cocaine use
- For healthy controls: negative urine drug test
You will not qualify if you...
- Diagnosis of other substance use disorders (except nicotine) according to DSM-5
- Primary major psychiatric disorders such as schizophrenia, bipolar disorder, or major depression
- History of significant or uncontrolled medical or neurological illness
- Current use of psychotropic or potentially psychoactive prescription medications
- Medical reasons that prevent MRI scanning
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Connecticut Mental Health Center
New Haven, Connecticut, United States, 06519
Actively Recruiting
Research Team
M
Marcella Mignosa, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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