Actively Recruiting
Cocaine and Pentoxifylline (BED IN 47)
Led by William Stoops · Updated on 2025-11-18
30
Participants Needed
1
Research Sites
120 weeks
Total Duration
On this page
Sponsors
W
William Stoops
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This will be a human laboratory study evaluating the influence of pentoxifylline treatment on the effects of cocaine. Supported by and included in the Helping to End Addiction Long-term® (HEAL) Initiative.
CONDITIONS
Official Title
Cocaine and Pentoxifylline (BED IN 47)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to speak and read English
- Not seeking treatment for drug use at the time of the study
- Male or female between 18 and 55 years of age
- Recent smoked or intravenous cocaine use verified by benzoylecgonine positive urine
- Meets DSM-5 criteria for cocaine use disorder
- Medically and psychiatrically healthy apart from cocaine use disorder
- ECG results within normal limits as read by a cardiologist
- Females using effective birth control and not pregnant or breastfeeding
- No known allergies or contraindications to pentoxifylline
You will not qualify if you...
- Unable to speak or read English
- Seeking treatment for drug use
- Under 18 years or over 55 years of age
- No recent smoked or intravenous cocaine use verified by benzoylecgonine negative urine
- Does not meet DSM-5 criteria for cocaine use disorder
- Medically or psychiatrically unhealthy
- ECG results outside normal limits as read by a cardiologist
- Females not using effective birth control, pregnant, or breastfeeding
- Allergies or contraindications to pentoxifylline
- History of head trauma, seizure, CNS tumors, or use of medications lowering seizure threshold
- First-degree family history of seizures
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Psychopharmacology of Addiction Laboratory
Lexington, Kentucky, United States, 40507
Actively Recruiting
Research Team
W
William W Stoops, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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