Actively Recruiting
A Repository to Study Host-Microbiome Interactions in Health and Disease
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-06-04
600
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the human microbiome, which consists of bacteria and other microorganisms living on and inside the body, to understand how it affects health and disease. This observational study aims to build a repository of microbiome samples that can be used for future research. The study focuses on collecting biological specimens to improve testing methods and identify targets for new clinical trials related to microbiome-associated diseases. Participants of all ages, including healthy volunteers and those with various health conditions, are invited to provide samples such as stool, urine, saliva, vaginal fluid, breast milk, and cells from areas like the cheek, nose, mouth, skin, rectum, and vagina. Some samples can be collected at home using swabs, while blood samples may be drawn at a clinic or collected by finger or heel prick for young children. Intestinal and skin tissue samples may also be collected if participants undergo related medical procedures. During the study, participants will complete questionnaires about their medical history and diet. Researchers will collect and store various biological specimens to analyze the host microbiome response. These samples will help validate assays, optimize collection and processing techniques, and serve as controls for other studies. The study will continue until 2032, with ongoing monitoring of sample collection and analysis to support future microbiome research.
CONDITIONS
Brief Title
A Repository to Study Host-Microbiome Interactions in Health and Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged over 0 years; only participants over 3 years old will be seen at the NIH Clinical Center
- Willing to allow biological samples and data to be stored for future research
- Willing to provide at least one of the requested biological specimens such as stool, urine, saliva, or swabs
You will not qualify if you...
- Any condition that may put the individual at undue risk or make them unsuitable for participation as judged by the investigator
- For gastrointestinal and skin biopsies, individuals on blood thinners unless stopped for the procedure
- For gastrointestinal biopsies, history of gastrointestinal perforation with endoscopic biopsies
- For gastrointestinal biopsies, healthy children under 18 years old
- For skin biopsies, history of keloid formation
- For vaginal swabs and vaginal fluid, individuals who have not started menses
- For breast milk, non-lactating individuals
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Throughout study participation
Participants provide biological specimens such as stool, urine, saliva, or swabs to support assay validation and research.
1 to multiple visits depending on sample types and collection schedule
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Shira L Levy
S
Suchitra K Hourigan, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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