Actively Recruiting
A Repository to Study Host-Microbiome Interactions in Health and Disease
Led by National Institute of Allergy and Infectious Diseases (NIAID) · Updated on 2026-04-07
600
Participants Needed
1
Research Sites
460 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: The microbiome is the bacteria and other microorganisms that live inside and on the body. The microbiome is important for our health. Researchers study how the microbiome help people stay healthy. They study how the microbiome affects the body when people get sick. To do this research, they need samples of the microbiome living on the bodies of many people. The purpose of this natural history study is to collect microbiome samples in a repository. These samples will be used for future research. Objective: To collect microbiome samples from the body that can be used for future research. Eligibility: People of any age. Only those older than 3 years will be seen at the NIH clinic. Design: Participants will fill out a questionnaire. Topics will include their medical history and foods they eat. Participants will be asked to give 1 or more of the following: Stool, urine, saliva, vaginal fluid, and breastmilk. These samples can be collected at home and sent to the researchers. Cells from participants cheek, nose, mouth, skin, rectum, and/or vagina. The cells may be collected by rubbing the area with a sterile cotton swab. These procedures can also be done at home. Blood. Blood may be drawn using a needle inserted into a vein in the arm. For young children, blood may be collected by a prick on the heel or finger. Intestinal tissue samples. These may be collected from participants who are having an endoscopy or colonoscopy for other reasons. Skin tissue samples. These may be collected from participants who are having biopsies for other reasons.
CONDITIONS
Official Title
A Repository to Study Host-Microbiome Interactions in Health and Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants of any age; those older than 3 years will be seen at the NIH clinic
- Willing to allow biological samples and data to be stored for future research
- Willing to provide at least one of the requested biospecimens
You will not qualify if you...
- Any condition that may put the participant at undue risk or make them unsuitable for the study, as judged by the investigator
- Use of blood thinners for additional gastrointestinal and skin biopsies unless stopped for the procedure
- History of gastrointestinal perforation with endoscopic biopsies for additional gastrointestinal biopsies
- Healthy children under 18 years old for additional gastrointestinal biopsies
- History of keloid formation for skin biopsies
- Individuals who have not started menses for vaginal swabs and vaginal fluid
- Non-lactating individuals for breast milk collection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Shira L Levy
CONTACT
S
Suchitra K Hourigan, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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