Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
ID07509606

Acute Effect of Different Frequency of Whole Body Vibration on Lung Function, Respiratory Function, Upper Extremity Strength and Flexibility, Cardiac Autonomic Function, and Quality of Life in Healthy Adults and Moderate to Severe Chronic Obstructive Pulmonary Disease

Led by National Cheng Kung University · Updated on 2026-04-03

102

Participants Needed

1

Research Sites

138 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Chronic obstructive pulmonary disease (COPD) is a long-lasting lung condition that causes breathing difficulties, muscle weakness, and lowers quality of life. Physical inactivity worsens symptoms and raises the risk of death. Guidelines recommend regular aerobic and resistance exercise to improve health, but the best exercise intensity and duration for COPD patients remain unclear. This study aims to explore how different frequencies of whole-body vibration (WBV) affect lung and muscle function, heart health, and quality of life in people with COPD and healthy adults. Participants will receive whole-body vibration therapy at three different frequencies (15, 25, and 35 Hz) in a randomized order. Each frequency will be tested over one week with a washout period of at least 7 days between sessions. After testing all frequencies, participants will complete three more sessions at their final assigned frequency to assess cumulative effects. The study includes healthy adults aged 18 to 65 and COPD patients classified as GOLD stage II to IV. During the study, researchers will measure lung function, diaphragm movement and thickness, respiratory muscle strength, and heart and lung responses at baseline and after each vibration frequency. They will also assess upper limb strength and flexibility, heart rate variability, and quality of life using questionnaires. The study will track changes from the start through the final sessions over approximately six weeks to understand the immediate and lasting effects of WBV therapy.

CONDITIONS

Brief Title

Acute Effect of Different Frequency of Whole Body Vibration (WBV) on Healthy and Chronic Obstructive Pulmonary Disease (COPD)

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Healthy individuals aged 18 to 65 years with no prior whole-body vibration experience or exposure to vibration-related occupations or sports
  • Adults aged 18 years or older clinically diagnosed with COPD classified as GOLD stage II, III, or IV
  • COPD patients with no hospitalization or rehabilitation program participation in the past two months
  • Ability to comply with the exercise training program
Not Eligible

You will not qualify if you...

  • Pregnancy
  • Acute thrombosis
  • Severe cardiovascular disease
  • Presence of a cardiac pacemaker
  • Recent wounds from injury or surgery
  • Hip or knee implants
  • Acute hernia, intervertebral disc degeneration, or spondylolysis
  • Severe diabetes mellitus
  • Epilepsy
  • Recent infection
  • Severe migraine
  • Tumor
  • Recently implanted intrauterine device, metal pins, or metal plates
  • Kidney stones
  • Organ failure
  • Musculoskeletal, respiratory, neurological, or cardiovascular conditions causing acute or chronic pain
  • Participation in other research studies concurrently
  • Regular exercise habits involving moderate-intensity exercise three or more times per week
  • Severe respiratory diseases such as bronchiectasis, pulmonary fibrosis, asthma, or tuberculosis
  • Current smokers
  • Severe joint disease or history of lower extremity surgery
  • History of vitreous hemorrhage
  • Dependence on supplemental oxygen
  • Severe alcohol abuse (more than 80 g/day)
  • Severe malnutrition (BMI less than 19 kg/m²)
  • Altered consciousness or inability to comply with assessments

AI-Screening

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Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 6 weeks

Participants receive whole-body vibration at three different frequencies in a randomized order with at least 7 days washout between sessions, followed by three additional sessions at the final frequency to evaluate cumulative effects.

5 visits over 3 weeks for frequency sessions and 3 visits over 1 week for cumulative sessions

Trial Site Locations

Total: 1 location

1

National Cheng Kung University Hospital

Tainan, Taiwan, 701

Actively Recruiting

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Research Team

K

Kun-Ling Tasi, PhD

T

Ting-Ying Wu, B.S

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

3

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