Study of COPD Patient Types and Treatable Traits Tracking Outcomes and Characteristics Over 3 Years

What this Trial Is About

Chronic Obstructive Pulmonary Disease COPD is a complex and progressive lung condition with varying types and characteristics, including different phenotypes and endotypes. This research aims to study these variations and treatable traits in COPD patients in Hong Kong, where healthcare differs from other regions. The study will observe how these traits change over time and how they relate to patient outcomes like exacerbations, mortality, lung function decline, symptoms, and quality of life over a period of three years. Participants will be recruited from outpatient and inpatient settings at a hospital. This prospective observational study includes an initial baseline assessment covering demographics, lung function tests, breath and blood biomarkers, exercise capacity, symptoms, treatment history, and healthcare use. Follow-up includes telephone assessments every six months for exacerbation history and annual visits for repeated lung function and biomarker tests, symptom evaluations, and health status updates for three years. During the study, researchers will gather data through spirometry, exhaled nitric oxide measurements, breath and blood sample collections, questionnaires on symptoms and quality of life, and records of exacerbations and mortality. This detailed monitoring will help identify treatable traits and patient groups with similar features, aiming to better understand COPD progression and management in this population.

A Study on COPD Phenotypes, Endotypes and Treatable Traits