Comparison of a New Adapted CPR Algorithm Versus Standard Advanced Cardiac Life Support for Adults Experiencing Out-of-Hospital Cardiac Arrest

What this Trial Is About

Researchers are conducting a randomized controlled trial to compare two advanced cardiac life support ALS algorithms in adults over 18 years experiencing out-of-hospital cardiac arrest. The study aims to determine if the frequency of return of spontaneous circulation ROSC differs between the new adapted CPR algorithm and the standard ERC ALS 2025 protocol. This trial is led by Johannes Kepler University of Linz and focuses on treatment effectiveness during resuscitation. Participants are randomly assigned at the scene to either the control group receiving standard ALS care or the intervention group receiving a modified treatment. The new adapted CPR algorithm includes mechanical thorax compression using the LUCAS 3 device, head-up CPR, an impedance threshold device ITD module, arterial line placement, continuous epinephrine infusion via pump, and double sequence defibrillation. The control group receives standard procedures such as IV line placement, airway management, and optional intraosseous access. During the study, researchers will monitor the time to ROSC, levels of carbon dioxide, and other descriptive data during resuscitation efforts. The primary outcome is ROSC measured one minute after treatment. The trial spans from screening and enrollment at the time of cardiac arrest with resuscitation times under 21 minutes. Safety and futility are monitored by the emergency physician on scene. The study is expected to complete in March 2029.

Adapted Cardiopulmonary Resuscitation Study