Study of Advanced Radiotherapy Techniques in Women With Gynecologic Cancer Evaluating Treatment Effects and Long-Term Outcomes

What this Trial Is About

Researchers are conducting an observational study on patients with gynecologic cancers who have been treated with advanced radiotherapy techniques such as Image Guided Radiotherapy IGRT, Intensity Modulated Radiotherapy IMRT, and Stereotactic Body Radiotherapy SBRT. The study aims to analyze toxicity levels and clinical outcomes including tumor control and survival rates. The study includes patients treated at the IRCCS San Raffaele Scientific Institute between January 2005 and January 2024. The study involves reviewing clinical and dosimetric data from these patients to assess acute and late treatment-related toxicities and to evaluate outcomes like local, regional, and distant control of the cancer, disease-free survival, cancer-specific survival, and overall survival. Researchers will also explore factors that may predict toxicity, disease progression, and survival, including radiomic characteristics from imaging. Participants medical records and treatment details will be analyzed without any additional interventions. The primary measurements include survival without relapse or metastases over up to 120 months after radiotherapy completion, as well as acute toxicity within three months and late toxicity beyond three months after treatment. This long-term follow-up is intended to provide insights into the safety and effectiveness of advanced radiotherapy for gynecologic cancers.

Advanced Radiotherapy (ART) in Gynecological Cancer Patients (GYN-ART)