Actively Recruiting
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
Led by Novo Nordisk A/S · Updated on 2026-05-05
600
Participants Needed
72
Research Sites
115 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
CONDITIONS
Official Title
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female (sex at birth).
- Age 18 years or above at the time of signing the informed consent.
You will not qualify if you...
- Glycated haemoglobin (HbA1c) greater than or equal to 65% [48 millimoles per mole (mmol/mol)] as measured at screening.
- History of type 1 or type 2 diabetes mellitus.
- Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists, dual GLP 1/gastric inhibitory peptide (GIP) RAs, or amylin analogues before screening.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 72 locations
1
Pinnacle Research Group LLC
Anniston, Alabama, United States, 36207
Actively Recruiting
2
Diablo Clinical Research, Inc.
Walnut Creek, California, United States, 94598
Actively Recruiting
3
Florida Inst For Clin Res LLC
Orlando, Florida, United States, 32825
Actively Recruiting
4
Endeavor Health
Skokie, Illinois, United States, 60077
Not Yet Recruiting
5
Midwest Inst For Clin Res
Indianapolis, Indiana, United States, 46260
Actively Recruiting
6
Medication Mgmnt, LLC_Grnsboro
Greensboro, North Carolina, United States, 27405
Actively Recruiting
7
PMG Research of Wilmington LLC
Wilmington, North Carolina, United States, 28401
Actively Recruiting
8
UPA Ctr Weight and Eating Dis
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
9
Clinical Res Collaborative
Cumberland, Rhode Island, United States, 02864
Actively Recruiting
10
North Texas Endocrine Center
Dallas, Texas, United States, 75231
Not Yet Recruiting
11
UT Southwestern Med Cntr
Dallas, Texas, United States, 75390-9302
Actively Recruiting
12
Selma Medical Associates
Winchester, Virginia, United States, 22601-3834
Actively Recruiting
13
Rainier Clin Res Ctr Inc
Renton, Washington, United States, 98057
Actively Recruiting
14
Conexa
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, C1018ADE
Actively Recruiting
15
CICEMO- Consultorio (Av Directorio)
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1424CIQ
Actively Recruiting
16
Instituto de Investigaciones Clinicas Mar Del Plata
Mar del Plata, Buenos Aires, Argentina, B7600FZN
Actively Recruiting
17
CIPREC Pueyrredon
Buenos Aires, Argentina, C1119ACN
Actively Recruiting
18
Sydney Clinical Trials
Campbelltown, New South Wales, Australia, 2560
Actively Recruiting
19
Sydney Cardiometabolic Centre
Liverpool, New South Wales, Australia, 2170
Actively Recruiting
20
Hunter Diabetes Centre
Merewether, New South Wales, Australia, 2291
Not Yet Recruiting
21
Nightingale Research
Adelaide, South Australia, Australia, 5000
Not Yet Recruiting
22
Anima Research Center
Diepenbeek, Belgium, 3590
Not Yet Recruiting
23
AZ Groeninge - Kortrijk - Centrum Endo - Diabetologie
Kortrijk, Belgium, 8500
Not Yet Recruiting
24
Centre hospitalier universitaire de Liège (CHU de Liège)
Liège, Belgium, 4000
Not Yet Recruiting
25
AZ OOSTENDE (Campus DAMIAAN)
Ostend, Belgium, 8400
Not Yet Recruiting
26
DCC 1 - Lom EOOD
Lom, Bulgaria, 3600
Not Yet Recruiting
27
MHAT Med Line Clinic
Plovdiv, Bulgaria, 4000
Not Yet Recruiting
28
UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic
Plovdiv, Bulgaria, 4001
Not Yet Recruiting
29
AIPSOMCEMD ENDO MED CONSULT 2020 - Dr. Aleksander Botushanov EOOD
Plovdiv, Bulgaria, 4002
Not Yet Recruiting
30
SGHAT Dr. Shterev EOOD
Sofia, Bulgaria, 1330
Not Yet Recruiting
31
UMHAT Aleksandrovska EAD, Clinic of Endocrinology and Metabolic Diseases
Sofia, Bulgaria, 1431
Not Yet Recruiting
32
Medical Center Maraya Med EOOD
Sofia, Bulgaria, 1756
Not Yet Recruiting
33
AIPSMC Dr. Traykovska EOOD
Sofia, Bulgaria, 1839
Not Yet Recruiting
34
Sjællands Universitetshospital, Køge - Medicinsk Afdeling
Køge, Region Sjælland, Denmark, 4600
Not Yet Recruiting
35
Sydvestjysk Sygehus Esbjerg - Medicinsk Endokrinologisk Ambulatorium, Forskningsenheden
Esbjerg, Region Syddanmark, Denmark, 6700
Not Yet Recruiting
36
Sanos Clinic - Vejle
Vejle, Region Syddanmark, Denmark, 7100
Not Yet Recruiting
37
CHU DE CLERMONT-FERRAND-HOPITAL GABRIEL MONTPIED_Service de Nutrition
Clermont-Ferrand, France, 63000
Not Yet Recruiting
38
CHU GRENOBLE ALPES-SITE NORD MICHALLON_Endocrinologie,diabétologie,maladies de la nutrition
La Tronche, France, 38700
Not Yet Recruiting
39
GROUPE SOS SANTE-HOPITAL LE CREUSOT-HOTEL DIEU_ Service de Diabétologie
Le Creusot, France, 71200
Actively Recruiting
40
CHU LILLE-HOPITAL CLAUDE HURIEZ_Service de Chirurgie Générale et Endocrinienne
Lille, France, 59000
Actively Recruiting
41
CHU DE POITIERS_Centre d'investigation Clinique
Poitiers, France, 86000
Not Yet Recruiting
42
Diabetologikum - Diabetologische Schwerpunktpraxis Dr. Thomas Segiet
Speyer, LÄK Rheinland-Pfalz, Germany, 67346
Not Yet Recruiting
43
Wendisch - Dahl Hamburg - DZHW
Hamburg, Germany, 22607
Not Yet Recruiting
44
Prof. Dr. Schiefke Ingolf, EUGASTRO GmbH
Leipzig, Germany, 04103
Not Yet Recruiting
45
Diabetologische Gemeinschaftspraxis Dr. Staudenmeyer und Dr. Schiwietz
Lingen, Germany, 49808
Not Yet Recruiting
46
Institut für Diabetesforschung GmbH Münster - Dr. med. Rose
Münster, Germany, 48145
Not Yet Recruiting
47
RED-Institut für medizinische Forschung und Fortbildung GmbH
Oldenburg in Holstein, Germany, 23758
Not Yet Recruiting
48
Zentrum für klinische Studien Alexander Segner
Saint Ingbert-Oberwürzbach, Germany, 66386
Not Yet Recruiting
49
Arcispedale Sant'Anna (Cona) - UO di Endocrinologia
Ferrara, Emilia-Romagna, Italy, 44124
Not Yet Recruiting
50
IRCCS Ospedale Policlinico San Martino - Medicina Interna e Specialità Mediche
Genoa, Liguria, Italy, 16132
Not Yet Recruiting
51
Fondazione Salvatore Maugeri I.R.C.C.S. - Pavia - Dipartimento Medicina Interna e Generale
Pavia, Lombardy, Italy, 27100
Not Yet Recruiting
52
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone - Presidio Villa Belmonte
Palermo, Sicily, Italy, 90127
Not Yet Recruiting
53
Azienda Ospedaliera di Padova - UOSD Chirurgia Bariatrica
Padova, Veneto, Italy, 35128
Not Yet Recruiting
54
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Geriatria
Verona, Veneto, Italy, 37126
Not Yet Recruiting
55
A.O.Universitaria S.ORSOLA-MALPIGHI - U.O.Endocrinologia e Cura
Bologna, Italy, 40138
Not Yet Recruiting
56
IRCCS Humanitas - U.O. Endocrinologia e Diabetologia
Rozzano (MI), Italy, 20089
Not Yet Recruiting
57
PreCare Trial & Recruitment
Born, Limburg, Netherlands, 6121 XK
Not Yet Recruiting
58
Progress Clinical Research Den Bosch
's-Hertogenbosch, North Brabant, Netherlands, 5223 LA
Not Yet Recruiting
59
EB Flevo Research BV
Almere Stad, Netherlands, 1311RL
Not Yet Recruiting
60
Meander MC
Amersfoort, Netherlands, 3813 TZ
Not Yet Recruiting
61
Rijnstate Ziekenhuis
Arnhem, Netherlands, 6815 AD
Not Yet Recruiting
62
Centro Periferico De Especialidades Bola Azul
Almería, Spain, 04009
Not Yet Recruiting
63
Hospital Clinic i Provincial
Barcelona, Spain, 08036
Not Yet Recruiting
64
H. de León_Endocrinología
León, Spain, 24008
Not Yet Recruiting
65
Hospital Clínico San Carlos
Madrid, Spain, 28040
Not Yet Recruiting
66
H. Clinico Univ. Virgen de la Victoria
Málaga, Spain, 29010
Not Yet Recruiting
67
H.U. Quirónsalud Madrid
Pozuelo de Alarcón, Spain, 28223
Not Yet Recruiting
68
Hospital Universitario Virgen del Rocío
Seville, Spain, 41013
Not Yet Recruiting
69
EMS Healthcare
Cheshire, United Kingdom, CH65 4LE
Actively Recruiting
70
Clifton Medical Centre
Rotherham, United Kingdom, S65 1DA
Actively Recruiting
71
Staploe Medical Centre
Soham, United Kingdom, CB7 5JD
Actively Recruiting
72
Albany House Medical Centre
Wellingborough, United Kingdom, NN8 4RW
Actively Recruiting
Research Team
N
Novo Nordisk
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here