Deep and unbiased proteomics, pathway enrichment analysis, and protein-protein interaction of biomarker signatures in migraine.
Yohannes W Woldeamanuel, Bharati M Sanjanwala, Robert P Cowan
https://pubmed.ncbi.nlm.nih.gov/39314676Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID03231241
SunStar Project to Explore the Chronification Process in Headache Through Functional Imaging, Deep Phenotyping, and Analysis of CSF of Blood Products
Led by Stanford University · Updated on 2025-07-23
700
Participants Needed
1
Research Sites
2 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying why some people with episodic headaches develop chronic daily or near daily headaches. The study aims to understand differences in brain anatomy and function, cerebrospinal fluid and blood components, genetics, and patient characteristics that may explain this change. This research hopes to improve understanding of chronic migraines and daily headaches to help develop better treatments and prevention methods. Participants may take part in online questionnaires, blood sampling, lumbar puncture (spinal tap), and MRI brain scans without contrast. Participants can choose to have the MRI or lumbar puncture but must complete at least three of the procedures including the blood draw and questionnaires. The study includes three groups: those with episodic headaches, chronic headaches, and people with few or no headaches. During the study, participants provide survey answers, biological samples, and imaging data to help researchers analyze brain and bodily differences linked to headache patterns. The main outcome is to predict headache chronification over five years. The study welcomes healthy volunteers aged 18 and older and does not provide any treatment or intervention. Participants will be monitored through their involvement in questionnaires and procedures over the study period ending in 2026.
CONDITIONS
Brief Title
Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Subjects must agree to sign informed consent.
- Must be able or willing to complete online questionnaires in English.
- Willing to follow study instructions.
- Must speak and understand English.
- Adults aged 18 years or older.
You will not qualify if you...
- Any neurological condition, at the discretion of the Principal Investigator.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Single timepoint
Participants complete online questionnaires, provide a blood sample, and may undergo an MRI scan and/or lumbar puncture to collect data for analysis.
1 visit (in-person) plus online questionnaires
Long-term Monitoring
Duration - Up to 5 years
Participants are followed over time to observe headache chronification and disease progression without receiving any interventions.
Periodic assessments as scheduled by the study
Trial Site Locations
Total: 1 location
1
Stanford University School of Medicine
Stanford, California, United States, 94304
Actively Recruiting
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Research Team
B
Bharati Sanjanwala, M.Sc.
A
Anthony Bet, B.S.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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