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Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
Led by Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · Updated on 2025-05-02
300
Participants Needed
4
Research Sites
N/A
Total Duration
On this page
Sponsors
H
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Lead Sponsor
J
Johns Hopkins University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how brain and spinal cord structures relate to chronic pain and sensory problems in people with cerebral palsy (CP). This study aims to identify patterns of disruption in the sensorimotor network linked to chronic pain and motor difficulties in CP. It also seeks to better understand brain network changes connected to sensory loss and pain, using MRI biomarkers to help improve diagnosis and treatment plans. The study involves several groups including individuals with CP and neurotypical controls, some completing only surveys and others also undergoing MRI scans. The MRI scans are performed using a 3T Philips scanner over about 1.5 hours without sedation or contrast agents, focusing on brain and selected spinal levels. These scans will be done within three months of survey completion when possible, with follow-up surveys if scans occur later. The study uses functional and anatomical imaging to analyze brain volume and diffusion measures. Participants will complete standardized online questionnaires about pain symptoms, demographics, and medical history. Medical records and previous clinical MRIs may be reviewed to correlate brain injury markers with pain and CP. The main outcomes measured are regional brain and spine volumes and diffusion metrics within three months. The study emphasizes non-invasive procedures and includes both children and adults aged 8 and older, with monitoring for changes in clinical status over time.
CONDITIONS
Brief Title
Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individual 8 years of age or older
- Diagnosis of cerebral palsy for CP groups
- Ability to provide consent or assent with legal representative consent
- Clinical imaging showing isolated periventricular white matter injury for CP Survey + MRI group
- Neurologic symptoms attributed to non-progressive periventricular white matter injury for CP Survey + MRI group
- Ability to lie still in an MRI scanner for up to 1.5 hours for MRI groups
- No clinically significant neurologic or developmental diagnosis for neurotypical participants
- Adult neurotypical participants able to provide consent
You will not qualify if you...
- Clinically significant neurologic or developmental diagnosis for neurotypical participants
- None listed for cerebral palsy participants
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or online)
Duration - Up to 3 months from initial survey
Participants complete standardized online questionnaires about pain symptoms, demographics, and medical history. Medical records and previously acquired clinical MRIs may be reviewed if consent is given.
1 to 2 visits depending on whether MRI is performed
Duration - Within 3 months of initial survey; timing may vary
Participants undergo research unsedated MRI scans including brain and selected spinal levels imaging using a 3T Philips scanner. MRI sessions last up to 1.5 hours and may be split into at most 2 sessions.
Up to 2 MRI sessions (in-person)
Trial Site Locations
Total: 4 locations
1
F.M. Kirby Center
Baltimore, Maryland, United States, 21205
Actively Recruiting
2
Mt. Washington Pediatric Hospital
Baltimore, Maryland, United States, 21209
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3
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
4
Kennedy Krieger Institute
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
P
Paul Salib, MS
E
Eric Chin, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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