Actively Recruiting

Age: 18Years - 100Years
All Genders
ID06069232

Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction (ARISTOTLE)

Led by Sun Yat-sen University · Updated on 2023-10-12

2000

Participants Needed

7

Research Sites

N/A

Total Duration

On this page

Sponsors

S

Sun Yat-sen University

Lead Sponsor

F

First Affiliated Hospital, Sun Yat-Sen University

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to better understand patients diagnosed with aortic valve disease, including aortic insufficiency and aortic valve stenosis, during hospitalization. The study is a multicenter cohort study focused on evaluating risk factors that affect patient outcomes. Researchers will use this information to develop a model that can help guide clinical decisions for people with these heart valve conditions. Participants diagnosed with aortic valve disease will be followed over time to observe their health outcomes. The study will monitor events such as all-cause death and cardiovascular complications, including whether patients undergo aortic valve replacement. No specific treatments or interventions are assigned, as this is an observational study. During the study, participants will be observed from baseline until death or the end of the follow-up period. Researchers will collect data on mortality and cardiovascular events to analyze prognostic risk factors. The primary outcome is all-cause mortality, while secondary outcomes include cardiovascular death and valve replacement. This ongoing observation will help improve understanding of the disease progression and patient prognosis.

CONDITIONS

Brief Title

Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction

Who Can Participate

Age: 18Years - 100Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • Diagnosed with aortic valve disease
Not Eligible

You will not qualify if you...

  • Had aortic valve replacement surgery before starting the study

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Long-term Monitoring

Duration - Up to approximately 5 years until study completion

Participants are observed over time to assess outcomes related to aortic valve disease.

Trial Site Locations

Total: 7 locations

1

First Affiliated Hospital, Sun Yat-Sen University

Guangzhou, Guangdong, China, 510000

Actively Recruiting

2

Third Affiliated Hospital, Sun Yat-Sun University

Guangzhou, Guangdong, China, 510000

Actively Recruiting

3

Jieyang People's Hospital

Jieyang, Guangdong, China, 522000

Actively Recruiting

4

Second Affiliated Hospital of Shantou University Medical College

Shantou, Guangdong, China, 515041

Actively Recruiting

5

Eighth Affiliated Hospital, Sun Yat-Sen University

Shenzhen, Guangdong, China, 518000

Actively Recruiting

6

Affiliated Hospital of Guangdong Medical University

Zhanjiang, Guangdong, China, 524001

Actively Recruiting

7

Zhongshan People's Hospital

Zhongshan, Guangdong, China, 528400

Actively Recruiting

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Research Team

X

xiaodong zhuang, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

Evaluation of EuroSCORE II to Determine the Prognosis of Patients With Moderate-To-Severe Aortic Stenosis: A Long-Term Retrospective Study.

Xianzhen Cai, Danchun Hu, Baoxin Yan...

https://pubmed.ncbi.nlm.nih.gov/41789337

Association between cholesterol, high-density lipoprotein, and glucose index and risks of cardiovascular and all-cause mortality in patients with calcific aortic valve stenosis: the ARISTOTLE cohort study.

Zhen Guo, Zhenyu Xiong, Wenjing Zhang...

https://pubmed.ncbi.nlm.nih.gov/41076530

Association Between the Malnutrition Status and All-Cause Mortality in Patients With Moderate and Severe Aortic Stenosis: A Prospective Cohort Study.

Bingzhen Li, Shaozhao Zhang, Chaoguang Xu...

https://pubmed.ncbi.nlm.nih.gov/39895526