Study of Transbronchial Cryobiopsy for Diagnosing Progressive Pulmonary Fibrosis in Adults

What this Trial Is About

Researchers are evaluating the diagnostic effectiveness, safety, and influencing factors of transbronchial cryobiopsy TBLC in people with progressive pulmonary fibrosis. The study aims to understand patient prognosis, health economic impacts, and how therapeutic strategies may change following TBLC. Participants diagnosed with progressive pulmonary fibrosis will be randomly divided into two groups to receive either transbronchial lung biopsy TBLB or TBLC. The study compares two procedures transbronchial cryobiopsy, a newer technique used to diagnose various diffuse lung diseases, and transbronchial lung biopsy, a more commonly used and relatively safe diagnostic method. These procedures will be performed to assess their diagnostic value and safety in this patient population. Participants are assigned randomly to one of these two biopsy methods. During the study, participants will be monitored for diagnostic performance one month after biopsy. Safety assessments will be conducted at seven days and one month after the procedure. Researchers will collect data on lung function, imaging, and clinical status to evaluate outcomes. The study will continue until the end of 2026, with detailed follow-up to measure the impact of each biopsy technique on diagnosis and patient care.

Application of Transbronchial Cryobiopsy in the Diagnosis of Progressive Pulmonary Fibrosis