Actively Recruiting
Assessing the Performance of Shotgun Metagenomics in the Diagnosis of Complex Prosthetic Joint Infections
Led by University Hospital, Brest · Updated on 2025-02-05
143
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objectiveof this of a prospective, multicentre study is to evaluate the performance of shotgun metagenomics in the diagnosis of chronic Prosthetic joint infection (PJI) in comparison with the adapted MSIS diagnostic score.. The main questions it aims to answer are: * To evaluate the performance of shotgun metagenomics in the diagnosis of chronic PJI in comparison with culture. * To describe the epidemiology of bacterial species responsible for chronic PJI in Western France and their potential resistance to antibiotics. * Analyzing the diagnostic performance of shotgun culture and metagenomics as a function of potentially administered antibiotic treatments A total of 143 patients sampled will be included. Six intraoperative samples will be taken for each patient, as part of routine care. In addition to the standard preoperative check-up, an extra volume of blood will be taken for CRP measurement at inclusion.
CONDITIONS
Official Title
Assessing the Performance of Shotgun Metagenomics in the Diagnosis of Complex Prosthetic Joint Infections
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female aged 18 years or older
- Patients being considered for surgery for suspected chronic PJI (more than 3 months since joint replacement surgery)
- Affiliated with social security
- No objection to participating in the study
You will not qualify if you...
- Suspicion or documentation of acute bacteremia at time of inclusion
- Patients under guardianship or trusteeship
- Pregnant or breastfeeding women
- Patient deprived of liberty by legal or administrative decision
- Patients in psychiatric care
AI-Screening
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Trial Site Locations
Total: 1 location
1
Brest university hospital
Brest, France, 29200
Actively Recruiting
Research Team
C
claudi LAMOUREUX, Dr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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