Actively Recruiting
Assessment of Nerve Involvement by MRI Using Diffusion Tensor and Resting State Functional Connectivity in Patients with Essential Trigeminal Neuralgia
Led by Fondation Ophtalmologique Adolphe de Rothschild · Updated on 2025-06-11
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating nerve involvement in patients with essential trigeminal neuralgia, a common type of facial pain that can be resistant to medication and disabling treatments. This study aims to improve the diagnosis and surgical decision-making by using advanced MRI techniques, including diffusion tensor imaging (DTI) and resting state functional MRI (fMRI), in addition to standard anatomical MRI. The study is prospective and involves patients referred for neurosurgery or pain management for unilateral essential trigeminal neuralgia. Participants will undergo a specialized MRI exam using a 3 Tesla machine that includes standard anatomical sequences with contrast injection, a diffusion tensor imaging sequence to analyze nerve fibers, and a resting state functional MRI to examine brain connectivity. The total MRI scan lasts about 45 minutes, with the added sequences taking approximately 15 minutes. This imaging approach is designed to better characterize nerve damage and vascular conflicts that may influence treatment. During the study, researchers will assess micro-structural changes in the trigeminal nerve at the time of inclusion. Patients will receive the MRI exam as part of their evaluation, and the imaging results will be used to guide treatment decisions. The study will monitor how these imaging techniques correlate with nerve involvement and surgical outcomes, helping to improve future diagnosis and management of trigeminal neuralgia.
CONDITIONS
Brief Title
Assessment in Patients With Essential Trigeminal Neuralgia of Nerve Involvement by MRI in DTI and Functional Connectivity in "Resting State"
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years and older
- Referred to neurosurgery or pain center for unilateral essential trigeminal neuralgia
- Undergoing assessment for vasculo-nervous conflict
You will not qualify if you...
- Neurodegenerative or inflammatory neurological diseases
- Previous microvascular decompression surgery
- Absolute contraindication to MRI
- Legal protection measures or impaired judgment preventing informed consent
- Pregnant or breastfeeding women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 day
Participants undergo MRI scans including standard anatomical sequences, diffusion tensor imaging (DTI), and resting state functional MRI to assess nerve involvement.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Fondation Ophtalmologique de Rothschild
Paris, France, 75019
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
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