Pain Relief Reverses Hippocampal Abnormalities in Trigeminal Neuralgia.
Alborz Noorani, Peter Shih-Ping Hung, Jia Y Zhang...
https://pubmed.ncbi.nlm.nih.gov/34380093Actively Recruiting
Age: 35Years - 60Years
All Genders
Healthy Volunteers
ID06518421
The Role of Limbic Subcortical Structures and Cognition in Chronic Neuropathic Pain
Led by University Health Network, Toronto · Updated on 2024-07-24
400
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic pain affects one in four Canadians and often leads to significant challenges including memory difficulties and fear of unexpected pain. This research focuses on trigeminal neuralgia (TN), a severe form of facial pain that serves as a model to better understand chronic neuropathic pain. The study aims to explore how chronic pain affects brain structures related to emotion and memory, such as the hippocampus and amygdala, and how these changes relate to cognitive function and pain experiences. Researchers will use advanced brain imaging and cognitive assessments to study 340 participants, including 170 with TN and 170 healthy controls matched by age and sex. Participants with TN will undergo MRI scans and neuropsychological assessments before and six months after surgical treatment, while healthy controls will be assessed once. The study will examine brain structure changes, memory performance, and pain-related fear using specialized tasks and questionnaires. Participants will take part in brain imaging, cognitive tests, and questionnaires to assess memory, emotion, and pain-related fear at specified time points. Key outcome measures include various neuropsychological assessments and MRI scans to monitor brain structure and function before and after surgery. The study also collects data on recalled pain memories and other clinical information to understand the relationship between brain changes, cognitive function, and chronic pain over time.
CONDITIONS
Brief Title
Emotion and Memory in Chronic Neuropathic Pain
Who Can Participate
Age: 35Years - 60Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age between 35 and 60 years old
- No active major neurological or psychiatric disorders
- No contraindications for MRI
- Able to communicate well enough to complete tasks and questionnaires
- Montreal Cognitive Assessment (MoCA) score greater than 23/30
- For trigeminal neuralgia group: experiencing TN pain for over 6 months
- Stable medication use
- Meeting established diagnostic criteria for trigeminal neuralgia (ICHD-3)
You will not qualify if you...
- Presence of other chronic pain or headache conditions
- Untreated hypertension or diabetes mellitus
- History of chronic drug or substance use disorder
- Chronic use of opioids or steroids
- Head trauma affecting cognitive performance
- Active psychiatric illness or current use of psychoactive medication
- History of multiple sclerosis, skull base injury, or tumors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Baseline assessments
Participants undergo brain imaging and neuropsychological assessments to evaluate brain structure, cognitive function, and pain-related fear and anxiety.
1 visit (in-person)
Surgical Treatment and Immediate Post-operative Care
Duration - Surgical period (duration not specified)
Participants with trigeminal neuralgia undergo surgical treatment for their condition.
Surgical procedure visit
Post-operative Follow-up
Duration - 6 months post-surgery
Participants are followed up with brain imaging, neuropsychological assessments, and memory-recall interviews to assess changes 6 months after surgery.
1 visit at 6 months post-surgery and additional memory-recall interview at 2 weeks post-surgery
Trial Site Locations
Total: 1 location
1
Toronto Western Hospital
Toronto, Ontario, Canada, M5T2S8
Actively Recruiting
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Research Team
J
Jacob Kim, BSc
P
Patcharaporn Srisaikaew, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Regional brain morphology predicts pain relief in trigeminal neuralgia.
Peter Shih-Ping Hung, Alborz Noorani, Jia Y Zhang...
https://pubmed.ncbi.nlm.nih.gov/34087549Selective hippocampal subfield volume reductions in classic trigeminal neuralgia.
Michael Frantisek Vaculik, Alborz Noorani, Peter Shih-Ping Hung...
https://pubmed.ncbi.nlm.nih.gov/31491821Schemas provide a scaffold for neocortical integration of new memories over time.
Sam Audrain, Mary Pat McAndrews
https://pubmed.ncbi.nlm.nih.gov/36184668Painful reminders: Involvement of the autobiographical memory system in pediatric postsurgical pain and the transition to chronicity.
Anna Waisman, Maria Pavlova, Melanie Noel...
https://pubmed.ncbi.nlm.nih.gov/35692557Remembering the pain of surgery 1 year later: a longitudinal examination of anxiety in children's pain memory development.
Melanie Noel, Brittany Rosenbloom, Maria Pavlova...
https://pubmed.ncbi.nlm.nih.gov/31335643