Actively Recruiting
Association of Periodontal Status and Smoking With Salivary Inflammasome Markers
Led by Uskudar University · Updated on 2026-01-21
116
Participants Needed
1
Research Sites
27 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to evaluate the relationship between periodontal status and salivary levels of the inflammasomes NOD-like receptor family, pyrin domain containing 3 (NLRP-3), NOD-like receptor family, pyrin domain containing 6 (NLRP-6), NOD-like receptor family, pyrin domain containing 12 (NLRP-12), NOD-like receptor family, CARD domain containing 5 (NLRC-5), interleukin-1 beta (IL-1β) and interleukin-10 (IL-10). Furthermore, this study aims to investigate whether the salivary levels of these inflammasomes may serve as potential diagnostic biomarkers for distinguishing individuals with periodontitis from those without. In addition, the potential role of smoking in modulating the relationship between periodontal status and salivary inflammasome levels will also be explored.
CONDITIONS
Official Title
Association of Periodontal Status and Smoking With Salivary Inflammasome Markers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be systemically healthy
- Have a clinical diagnosis of periodontitis
- Have a clinical diagnosis of periodontal health
You will not qualify if you...
- History of regular use of systemic antibiotics, anti-inflammatory, or antioxidant drugs within the past 6 months
- Received nonsurgical periodontal treatment within the past 6 months
- Received surgical periodontal treatment within the past 12 months
- Have fewer than 20 teeth
- Taking medications that affect gum health such as calcium channel blockers, phenytoin, cyclosporine, or hormone replacement therapy
- Diagnosis of diabetes or rheumatoid arthritis
- Pregnant, breastfeeding, or consume excessive alcohol
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Uskudar University, Faculty of Dentistry
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
K
Kubra KARADURAN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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