Neuron-Specific Enolase as a Biomarker: Biochemical and Clinical Aspects.
Maria Antonietta Isgrò, Patrizia Bottoni, Roberto Scatena
https://pubmed.ncbi.nlm.nih.gov/26530364Actively Recruiting
Age: 18Years - 80Years
All Genders
ID07165236
Association of Perioperative Cognitive Dysfunction With Circulating Biomarkers of Neurological Damage in Patients Undergoing Transurethral Resection of Bladder Tumor
Led by Osijek University Hospital · Updated on 2025-09-10
42
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Bladder tumor is a common cancer worldwide, especially affecting an elderly population with multiple health issues. Researchers are studying the connection between perioperative cognitive dysfunction and circulating biomarkers of neurological damage in patients undergoing transurethral resection of bladder tumor (TURM) under general anesthesia. This observational study focuses on identifying risk factors such as neuroinflammation, oxidative stress, and frailty that may influence cognitive decline after surgery in this vulnerable group. Participants in this study are adult patients aged 18 to 80 years scheduled for elective TURM surgery. The study will assess cognitive function using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) before and after surgery. Muscle strength will be measured with a hand grip test, and blood samples will be collected to measure organic function markers and circulating neuroinflammatory indicators such as S100B, neuron-specific enolase, IL4, and IL6 at multiple time points during the perioperative period. During the study, participants will undergo cognitive tests at baseline, 24 hours, and 48 hours after surgery, along with blood tests at baseline, 2 hours, and 24 hours post-surgery. Researchers will also assess clinical frailty and muscle strength to explore their relationship with cognitive changes. This comprehensive evaluation aims to better understand factors affecting postoperative cognitive outcomes, with safety monitoring continuing through the surgical and early recovery phases.
CONDITIONS
Brief Title
Association of POCD With Circulating Biomarkers in Patients Undergoing TUR of Bladder Tumor
Who Can Participate
Age: 18Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 to 80 years
- Elective surgery for bladder tumor (transurethral resection)
- Ability to communicate
- Ability to sign informed consent and complete questionnaires
You will not qualify if you...
- Patients younger than 18 years
- Patients older than 80 years
- Inability to communicate
- Inability to understand informed consent
- Inability to write
- Emergency surgery
- Known hypersensitivity to study drugs
- Patients in shock, septic, or with severe bleeding
- Patients with neurodevelopmental disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Surgery and Immediate Post-operative Care
Duration - 1 day
Participants undergo transurethral resection of the bladder under general anesthesia. Cognitive function and circulating biomarkers of neurological damage are assessed before and after surgery.
Assessments at baseline, 2 hours after surgery, 24 hours after surgery, and 48 hours after surgery
Trial Site Locations
Total: 1 location
1
Osijek UH
Osijek, Croatia, Croatia, 31000
Actively Recruiting
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Research Team
A
Ana Cicvarić
S
Slavica Kvolik, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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