Characteristics of Women with Urinary Tract Infection in Pregnancy.
Candice Y Johnson, Carissa M Rocheleau, Meredith M Howley...
https://pubmed.ncbi.nlm.nih.gov/34491115Actively Recruiting
Age: 18Years - 35Years
FEMALE
Healthy Volunteers
ID06962644
Association of Urinary Tract Infection With Preeclampsia During Pregnancy
Led by Pakistan Air Force (PAF) Hospital Islamabad · Updated on 2025-05-08
160
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Urinary tract infections (UTIs) are common bacterial infections, especially in pregnant women, and can lead to serious complications like preterm labor and low birth weight if untreated. Preeclampsia is a hypertensive disorder affecting 0.2 to 9.2% of pregnancies and is a leading cause of maternal and fetal complications. The connection between UTIs and preeclampsia is unclear, with some studies showing an association and others not. This study aims to investigate this link specifically in pregnant women in Pakistan, where these conditions significantly impact maternal and neonatal health. The study will enroll 160 pregnant women, half with UTIs and half without, from the Obstetrics Department of PAF Hospital in Islamabad. Participants must be between 18 and 35 years old and have a gestational age over 20 weeks. UTIs will be diagnosed using urine tests, while preeclampsia will be identified based on blood pressure and proteinuria criteria. The women will be followed until delivery, and data will be analyzed to assess the risk of preeclampsia associated with UTIs. During the study, participants will provide urine samples and undergo clinical evaluations. The research team will track the development of preeclampsia according to set definitions, while managing all patients as per hospital standards. Outcomes will be analyzed using statistical software, focusing on the relative risk of preeclampsia in women with and without UTIs. The study will also consider factors like age and gestational age to better understand this association.
CONDITIONS
Brief Title
Association of Urinary Tract Infection With Preeclampsia During Pregnancy
Who Can Participate
Age: 18Years - 35Years
FEMALE
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Patients attending outpatient department for routine antenatal checkup
- Patients diagnosed with urinary tract infection as per operational definitions
- Pregnant women with gestational age greater than 20 weeks as per last menstrual period
- Age between 18 to 35 years
You will not qualify if you...
- History of diabetes mellitus
- Chronic hypertension
- Chronic liver or kidney diseases
- Chronic pulmonary conditions
- History of urological surgical interventions in past 3 months
- History of renal transplants
- Patients on immunosuppressive therapy
- History of gestational diabetes mellitus
- History of hypertension
- Chronic hepatic diseases
- Ischemic heart diseases
- Use of drugs in the last month causing proteinuria such as NSAIDs, chemotherapeutic drugs, hydralazine, angiotensin receptor blockers
- History of coagulation disorders
- Patients unwilling to give consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for routine antenatal checkup and eligibility assessment
Monitoring
Duration - From enrollment after 20 weeks of pregnancy until parturition (up to approximately 17 weeks)
Participants are observed during pregnancy to assess the development of preeclampsia and urinary tract infection status.
Multiple antenatal visits as per routine prenatal care until delivery
Trial Site Locations
Total: 1 location
1
PAF Hospital, Islamabad
Islamabad, Pakistan, 45100
Actively Recruiting
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Research Team
W
Wajiha Fatima Resident, MBBS, FCPS (I)
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Pregnancy Outcomes in Patients with Urosepsis and Uncomplicated Urinary Tract Infections-A Retrospective Study.
Viorel-Dragos Radu, Petronela Vicoveanu, Alexandru Cărăuleanu...
https://pubmed.ncbi.nlm.nih.gov/38138232Urinary Tract Infections and Preeclampsia among Pregnant Women Attending Two Hospitals in Mwanza City, Tanzania: A 1:2 Matched Case-Control Study.
Joshua Kaduma, Jeremiah Seni, Clotilda Chuma...
https://pubmed.ncbi.nlm.nih.gov/31032344Risk factors for preeclampsia and eclampsia at a main referral maternity hospital in Freetown, Sierra Leone: a case-control study.
N Stitterich, J Shepherd, M M Koroma...
https://pubmed.ncbi.nlm.nih.gov/34078312Association Between Urinary Tract Infection in the First Trimester and Risk of Preeclampsia: A Case-Control Study.
Aazam Taghavi Zahedkalaei, Mahdiye Kazemi, Pouneh Zolfaghari...
https://pubmed.ncbi.nlm.nih.gov/32765118Factors contributing to preterm birth in patients presenting at tertiary care hospitals in Punjab.
Fariha Aslam Bajwa, Nayyer Sultana, Ameelia Sadaqat...
https://pubmed.ncbi.nlm.nih.gov/38591287Prevalence of Urinary Tract Infection and Its Associated Factors among Pregnant Women in Ethiopia: A Systematic Review and Meta-Analysis.
Temesgen Getaneh, Ayenew Negesse, Getenet Dessie...
https://pubmed.ncbi.nlm.nih.gov/34901276Urinary tract infections and antibiotic use in pregnancy - qualitative analysis of online forum content.
Flavia Ghouri, Amelia Hollywood, Kath Ryan
https://pubmed.ncbi.nlm.nih.gov/31409404