Indoor air quality impacts of residential mechanical ventilation system retrofits in existing homes in Chicago, IL.
Insung Kang, Anna McCreery, Parham Azimi...
https://pubmed.ncbi.nlm.nih.gov/34798726/Actively Recruiting
Led by The University of Texas at Arlington · Updated on 2025-10-29
80
Participants Needed
2
Research Sites
4 weeks
Total Duration
This research aims to evaluate the long-term effectiveness of two devices, energy recovery ventilators ERVs and portable air cleaners PACs, in lowering indoor air pollutants and mold while improving asthma-related health outcomes among children and adults with asthma living in low-income households in the Dallas-Fort Worth metropolitan area. The study uses a double-blind, placebo-controlled randomized controlled design to compare these interventions over a year, focusing on asthma control, quality of life, stress, and sleep quality. Participants will be randomly assigned to one of four groups an active ERV, a placebo ERV operating only in recirculation mode, an active PAC, or a placebo PAC lacking HEPA and carbon filters. The ERVs use filters to clean incoming outdoor air, while PACs filter indoor air pollutants. The study includes baseline housing assessments and indoor air measurements to understand environmental factors affecting asthma and the impact of these devices. Participants will undergo comprehensive health assessments including lung function tests and monthly asthma control surveys for up to two years, covering one year before and one year after the intervention begins. Additional assessments include quality of life, stress, and sleep evaluations using validated questionnaires during home visits. Environmental exposures, housing conditions, and asthma outcomes will be monitored to measure the effects of the interventions, with safety and health tracked throughout the study period.
CONDITIONS
Asthma Intervention With Residential Ventilation and Air Cleaner (AIRVAC) Study
I
Insung Kang, Ph.D.
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The University of Texas at Arlington
Lead Sponsor
Rebuilding Together North Texas
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Active ERV | Sham ERV | Active PAC | Sham PAC |
|---|---|---|---|---|
| What it is | A home-installed mechanical Energy Recovery Ventilator (ERV) that brings fresh outside air into the home while transferring heat and moisture for improved indoor air quality. | A home-installed ERV device set to run in recirculation mode only; no outside air is brought in and no air cleaning occurs (placebo control). | A portable air cleaner device equipped with a HEPA filter that actively removes airborne particles, allergens, and pollutants from indoor home air. | A portable air cleaner present in the home but lacking a HEPA filter and not providing actual air filtration; serves as a placebo comparator. |
| Role in trial | Active investigational arm; tests whether real home mechanical ventilation improves asthma outcomes compared to placebo. | Placebo comparator for the ERV arm, allowing effects of ventilation to be separated from expectations or installer entry. | Active investigational arm; evaluates whether an operating portable air cleaner improves indoor air and associated asthma outcomes compared to placebo. | Placebo comparator used to control for the presence, operation, and appearance of an air cleaner device without actual filtration. |
| Primary use | Continuous fresh air exchange and humidity transfer, aiming to improve indoor air quality and support asthma management. | Serves as a visual and operational placebo; does not perform real air exchange or filtration. | Filters airborne particulates and contaminants to reduce triggers for asthma and improve air quality. | Mimics the appearance and sound of a working air cleaner but does not filter air; provides placebo comparison. |
| How it is given or performed | An ERV device is professionally installed in the home and operates continuously, exchanging indoor and outdoor air during the trial. | An identical ERV device is installed but configured in a way that prevents ventilation, with operation limited to recirculating indoor air. | A portable air cleaner with a HEPA filter is placed in the home and remains in operation per protocol instructions for the study duration. | A device identical in appearance operates in the home but lacks a working filter and does not clean the air. |
| Evidence status | Effectiveness of mechanical ERV for asthma control in homes is under active study; evidence in other populations suggests benefits for indoor air quality but not yet established for asthma outcomes in this population. | The sham ERV is not expected to change air quality or asthma outcomes. Placebo effect may influence perceived results. | Portable air cleaners with HEPA filters are shown to reduce airborne particulates; evidence for direct improvement in asthma control in homes is still being studied in this population. | No active filtration occurs; sham PAC is not expected to reduce air pollutants or affect asthma beyond potential placebo effects. |
| Important limitations | Impact on asthma control is still under investigation; device effectiveness may vary based on home characteristics and participant adherence to use. | Does not improve air quality and provides no real therapeutic benefit; perceptions may be influenced by expectation bias. | Benefits may depend on whether the device is operated continuously as instructed and on the type of airborne pollutants present; effect on asthma outcomes must still be confirmed in this population. | No real filtration or air cleaning, so cannot address air pollutant exposures; may influence expectations or reporting but not air quality. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 year
Participants are randomized to receive one of four home device interventions: an active energy recovery ventilator, a sham energy recovery ventilator, an active portable air cleaner, or a sham portable air cleaner, installed in their homes.
Monthly home visits for asthma control assessments and periodic home visits for quality of life, stress, and sleep evaluations at baseline, 6, 18, and 24 months
Duration - 1 year
Participants are observed for ongoing asthma control, indoor air quality, and health outcomes following the intervention period.
Monthly asthma control assessments continuing through the full 24 months with additional home visits at 18 and 24 months for comprehensive evaluations
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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https://pubmed.ncbi.nlm.nih.gov/40468409/The University of Texas at Arlington
Lead Sponsor
Rebuilding Together North Texas
Collaborating Sponsor