Study of Blue Light Effects on Vagus Nerve Stimulation in Adults with Refractory Epilepsy and Healthy Volunteers

What this Trial Is About

Researchers are studying how exposure to blue enriched light may influence the effects of vagus nerve stimulation VNS in patients with refractory epilepsy. VNS is a treatment used when epilepsy does not respond well to other therapies, but many patients still have insufficient response. This study aims to explore how blue light affects biomarkers related to VNS action, which could lead to new ways to improve therapy effectiveness. Participants include patients with implanted VNS devices and healthy subjects. They will not receive drugs but will take part in experiments involving electroencephalography brain activity recording, pupillometry measuring pupil size, electrocardiography heart activity recording, evoked potentials, and light administration. The study will assess how blue light impacts these physiological parameters during VNS. During the study, participants will undergo various recordings and light exposure sessions while researchers monitor brain, heart, and pupil responses. The main outcome measured is the effect of blue light on VNS biomarkers over a period of up to four years. The study is single-blinded and non-randomized, and healthy volunteers are included. Participants will be followed to understand possible changes in VNS effects with blue light exposure.

Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy