Actively Recruiting
Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy
Led by Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Updated on 2025-09-10
34
Participants Needed
1
Research Sites
143 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Vagus nerve stimulation (VNS) is an adjunctive treatment for refractory epilepsy. Although widely used, there is still a substantial number of patients with insufficient response. Light, and particularly blue light, can stimulate alertness, attention and cognition through modulation of anatomical targets which are common to the vagal afferent network. This project aims at understanding how exposure to blue enriched light may influence VNS effects in patients with refractory epilepsy by exploring the modulation of a series of biomarkers of VNS action. This could possibly lead to new therapeutic strategies to increase efficacy of VNS.
CONDITIONS
Official Title
Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18 to 60 years with a vagus nerve stimulator implanted for at least 3 months
- IQ greater than 55 on the Wechsler scale (normal or mild cognitive impairment)
- Healthy participants aged between 18 and 35 years without any neurological or psychiatric medical history
You will not qualify if you...
- Presence of other implanted medical devices besides VNS in patients
- Eye diseases in patients
- Healthy participants with implanted medical devices
- Healthy participants with cerebral trauma
- Healthy participants with eye diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Cliniques Universitaires Saint Luc
Woluwe-Saint-Lambert, Belgium, 1200
Actively Recruiting
Research Team
I
Inci cakiroglu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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